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PMID:14576442
| Citation |
Ruefli-Brasse, AA, French, DM and Dixit, VM (2003) Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase. Science 302:1581-4 |
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| Abstract |
Paracaspase (MALT1), a member of an evolutionarily conserved superfamily of caspase-like proteins, has been shown to bind and colocalize with the protein Bcl10 in vitro and, because of this association, has been suggested to be involved in the CARMA1-Bcl10 pathway of antigen-induced nuclear factor kappaB (NF-kappaB) activation. We demonstrate that primary T and B lymphocytes from paracaspase-deficient mice are defective in antigen-receptor-induced NF-kappaB activation, cytokine production, and proliferation. Paracaspase acts downstream of Bcl10 to induce NF-kappaB activation and is required for the normal development of B cells, indicating that paracaspase provides the missing link between Bcl10 and activation of the IkappaB kinase complex. |
| Links |
PubMed Online version:10.1126/science.1090769 |
| Keywords |
Adaptor Proteins, Signal Transducing; Animals; Antibody Formation; Antigens, CD/analysis; B-Lymphocyte Subsets/immunology; B-Lymphocyte Subsets/physiology; B-Lymphocytes/immunology; B-Lymphocytes/metabolism; B-Lymphocytes/physiology; Caspases; Cell Differentiation; Cell Division; Cell Survival; Cells, Cultured; Cytokines/metabolism; Gene Deletion; Gene Targeting; Guanylate Kinase; I-kappa B Kinase; Lymphocyte Activation; Lymphoma, B-Cell, Marginal Zone/chemistry; Lymphoma, B-Cell, Marginal Zone/metabolism; Mice; Mice, Inbred C57BL; NF-kappa B/metabolism; Neoplasm Proteins/chemistry; Neoplasm Proteins/metabolism; Nucleoside-Phosphate Kinase/metabolism; Phosphorylation; Protein Structure, Tertiary; Protein-Serine-Threonine Kinases/metabolism; Receptors, Antigen, B-Cell/metabolism; Receptors, Antigen, T-Cell/metabolism; Signal Transduction; T-Lymphocyte Subsets/immunology; T-Lymphocyte Subsets/physiology; T-Lymphocytes/immunology; T-Lymphocytes/metabolism; T-Lymphocytes/physiology; Transfection |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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