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de la Cruz, IP, Levin, JZ, Cummins, C, Anderson, P and Horvitz, HR (2003) sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans. J. Neurosci. 23:9133-45


Genetic studies of sup-9, unc-93, and sup-10 strongly suggest that these genes encode components of a multi-subunit protein complex that coordinates muscle contraction in Caenorhabditis elegans. We cloned sup-9 and sup-10 and found that they encode a two-pore K+ channel and a novel transmembrane protein, respectively. We also found that UNC-93 and SUP-10 colocalize with SUP-9 within muscle cells, and that UNC-93 is a member of a novel multigene family that is conserved among C. elegans, Drosophila, and humans. Our results indicate that SUP-9 and perhaps other two-pore K+ channels function as multiprotein complexes, and that UNC-93 and SUP-10 likely define new classes of ion channel regulatory proteins.




Amino Acid Sequence; Animals; Caenorhabditis elegans/drug effects; Caenorhabditis elegans/physiology; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Cloning, Molecular; Exons; GABA Agonists/pharmacology; GTPase-Activating Proteins/genetics; Green Fluorescent Proteins; Introns; Luminescent Proteins/biosynthesis; Luminescent Proteins/genetics; Membrane Proteins/genetics; Membrane Proteins/metabolism; Molecular Sequence Data; Motor Activity/drug effects; Motor Activity/genetics; Motor Activity/physiology; Muscimol/pharmacology; Muscle Contraction/drug effects; Muscle Contraction/physiology; Muscle Proteins/metabolism; Nerve Tissue Proteins/genetics; Organ Specificity/genetics; Phenotype; Potassium Channels/genetics; Potassium Channels/metabolism; Potassium Channels, Tandem Pore Domain; Protein Subunits/metabolism; Saccharomyces cerevisiae Proteins/genetics; Sequence Homology, Amino Acid



Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status

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