GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:14499607
| Citation |
Grisoni, K, Gieseler, K, Mariol, MC, Martin, E, Carre-Pierrat, M, Moulder, G, Barstead, R and Ségalat, L (2003) The stn-1 syntrophin gene of C.elegans is functionally related to dystrophin and dystrobrevin. J. Mol. Biol. 332:1037-46 |
|---|---|
| Abstract |
Syntrophins are a family of PDZ domain-containing adaptor proteins required for receptor localization. Syntrophins are also associated with the dystrophin complex in muscles. We report here the molecular and functional characterization of the Caenorhabditis elegans gene stn-1 (F30A10.8), which encodes a syntrophin with homology to vertebrate alpha and beta-syntrophins. stn-1 is expressed in neurons and in muscles of C.elegans. stn-1 mutants resemble dystrophin (dys-1) and dystrobrevin (dyb-1) mutants: they are hyperactive, bend their heads when they move forward, tend to hypercontract, and are hypersensitive to the acetylcholinesterase inhibitor aldicarb. These phenotypes are suppressed when stn-1 is expressed under the control of a muscular promoter, indicating that they are caused by the absence of stn-1 in muscles. These results suggest that the role of syntrophin is linked to dystrophin function in C.elegans. |
| Links | |
| Keywords |
Aldicarb/pharmacology; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Calcium Channels/metabolism; Calcium-Binding Proteins; Databases as Topic; Dystrophin/physiology; Dystrophin-Associated Proteins; Genome; Genotype; Green Fluorescent Proteins; Humans; Luminescent Proteins/metabolism; Membrane Proteins/genetics; Membrane Proteins/physiology; Models, Biological; Muscle Proteins/genetics; Muscle Proteins/physiology; Muscles/pathology; Muscular Dystrophy, Duchenne/metabolism; Mutation; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/physiology; Neuropeptides/physiology; Phenotype; Phylogeny; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Sensitivity and Specificity; Two-Hybrid System Techniques |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
