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PMID:1398138
| Citation |
Bird, DM (1992) Sequence comparison of the Caenorhabditis elegans dpy-13 and col-34 genes, and their deduced collagen products. Gene 120:261-6 |
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| Abstract |
A 2232-nucleotide sequence spanning the col-34 gene from the nematode, Caenorhabditis elegans, is presented. This gene, which encodes a collagen protein (Clg), is transcribed from right to left with respect to the genetic map, and convergently with the nearby dpy-13 gene which also encodes a Clg. Both col-34 and dpy-13 have 5'-flanking elements in common with each other and also with other nematode Clg-encoding genes (clg). One element, variants of which are shared by col-7, col-19 and dpy-13, is predicted to be a target for a number of regulatory molecules, possibly including the ceh-18 product, a nematode POU-domain protein. The deduced amino acid sequence of Col-34 has a high degree of homology with the Dpy-13 collagen, although there are significant differences. In particular, one region of Dpy-13, which is predicted to have secondary structure different from Col-34, is altered by the recessive dpy-13(e225) mutation. |
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| Keywords |
Amino Acid Sequence; Animals; Caenorhabditis elegans/genetics; Cloning, Molecular; Collagen/genetics; Genes; Introns; Molecular Sequence Data; Restriction Mapping; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; TATA Box |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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