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PMID:12975350
| Citation |
Guild, GM, Connelly, PS, Ruggiero, L, Vranich, KA and Tilney, LG (2003) Long continuous actin bundles in Drosophila bristles are constructed by overlapping short filaments. J. Cell Biol. 162:1069-77 |
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| Abstract |
The actin bundles essential for Drosophila bristle elongation are hundreds of microns long and composed of cross-linked unipolar filaments. These long bundles are built from much shorter modules that graft together. Using both confocal and electron microscopy, we demonstrate that newly synthesized modules are short (1-2 microm in length); modules elongate to approximately 3 microm by growing over the surface of longitudinally adjacent modules to form a graft; the grafted regions are initially secured by the forked protein cross-bridge and later by the fascin cross-bridge; actin bundles are smoothed by filament addition and appear continuous and without swellings; and in the absence of grafting, dramatic alterations in cell shape occur that substitutes cell width expansion for elongation. Thus, bundle morphogenesis has several components: module formation, elongation, grafting, and bundle smoothing. These actin bundles are much like a rope or cable, made by overlapping elements that run a small fraction of the overall length, and stiffened by cross-linking. |
| Links |
PubMed PMC2172841 Online version:10.1083/jcb.200305143 |
| Keywords |
Actin Cytoskeleton/metabolism; Actin Cytoskeleton/ultrastructure; Animals; Body Patterning/physiology; Carrier Proteins/genetics; Cell Differentiation/physiology; Cells, Cultured; Drosophila melanogaster/growth & development; Drosophila melanogaster/metabolism; Drosophila melanogaster/ultrastructure; Mechanoreceptors/growth & development; Mechanoreceptors/metabolism; Mechanoreceptors/ultrastructure; Metamorphosis, Biological/physiology; Microfilament Proteins/deficiency; Microfilament Proteins/genetics; Microscopy, Confocal; Microscopy, Electron; Microscopy, Electron, Scanning; Pupa/growth & development; Pupa/metabolism; Pupa/ultrastructure |
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