GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:12876201
| Citation |
Granon, S, Faure, P and Changeux, JP (2003) Executive and social behaviors under nicotinic receptor regulation. Proc. Natl. Acad. Sci. U.S.A. 100:9596-601 |
|---|---|
| Abstract |
Nicotine enhances several cognitive and psychomotor behaviors, and nicotinic antagonists cause impairments in tasks requiring cognitive effort. To explore the contribution of nicotinic receptors to complex cognitive functions, we developed an automated method to investigate sequential locomotor behavior in the mouse and an analysis of social behavior. We show that, in the beta2-/- mutant, the high-order spatiotemporal organization of locomotor behavior, together with conflict resolution and social interaction, is selectively dissociated from low-level, more automatic motor behaviors. Such deficits in executive functions resemble the rigid and asocial behavior found in some psychopathological disorders such as autism and attention deficit hyperactivity disorder. |
| Links |
PubMed PMC170963 Online version:10.1073/pnas.1533498100 |
| Keywords |
Animals; Behavior, Animal; Cognition Disorders/etiology; Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Nicotine/metabolism; Receptors, Nicotinic/genetics; Receptors, Nicotinic/physiology; Time Factors |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
