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PMID:12817086

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Citation

González-Pastor, JE, Hobbs, EC and Losick, R (2003) Cannibalism by sporulating bacteria. Science 301:510-3

Abstract

Spore formation by the bacterium Bacillus subtilis is an elaborate developmental process that is triggered by nutrient limitation. Here we report that cells that have entered the pathway to sporulate produce and export a killing factor and a signaling protein that act cooperatively to block sister cells from sporulating and to cause them to lyse. The sporulating cells feed on the nutrients thereby released, which allows them to keep growing rather than to complete morphogenesis. We propose that sporulation is a stress-response pathway of last resort and that B. subtilis delays a commitment to spore formation by cannibalizing its siblings.

Links

PubMed Online version:10.1126/science.1086462

Keywords

Adenosine Triphosphate/metabolism; Bacillus subtilis/genetics; Bacillus subtilis/metabolism; Bacillus subtilis/physiology; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Bacteriolysis; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Genes, Bacterial; Mutation; Oligonucleotide Array Sequence Analysis; Operon; Sigma Factor/genetics; Sigma Factor/metabolism; Signal Transduction; Spores, Bacterial/physiology; Transcription Factors/genetics; Transcription Factors/metabolism; Transcription, Genetic

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

BACSU:SKFA

GO:0043934: sporulation

ECO:0000315:

P

In Figure 1C there is a graph that shows the amount of sporulation over time. The wild type that has a normal Skf gene shows a low amount of sporulation compared to the mutant Skf gene that shows a much larger amount of sporulation.

complete
CACAO 12544

Notes

See also

References

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