PMID:12736202

Citation	Battu, G, Hoier, EF and Hajnal, A (2003) The C. elegans G-protein-coupled receptor SRA-13 inhibits RAS/MAPK signalling during olfaction and vulval development. Development 130:2567-77
Abstract	In C. elegans, the RAS/MAPK pathway is used in different tissues to regulate various cell fate decisions. Several positive and negative regulators tightly control the activity of the RAS/MAPK pathway at different steps. We demonstrate a link between a G-protein-coupled receptor signalling pathway and the RAS/MAPK cascade. SRA-13, a member of the SRA family of chemosensory receptors, negatively regulates RAS/MAPK signalling during vulval induction and the olfaction of volatile attractants. Epistasis analysis indicates that SRA-13 inhibits the RAS/MAPK pathway at the level or upstream of MAPK. In both tissues, the vulval precursor cells and the chemosensory neurones, SRA-13 acts through the GPA-5 Galpha protein subunit, suggesting a common mechanism of crosstalk. Moreover, we find that vulval induction is repressed by food withdrawal during larval development and that SRA-13 activity is required for the suppression of vulval induction in response to food starvation. Thus, SRA-13 may serve to adapt the activity of the RAS/MAPK pathway to environmental conditions.
Links	PubMed
Keywords	Amino Acid Sequence; Animals; Caenorhabditis elegans/embryology; Caenorhabditis elegans/metabolism; Embryonic Induction/physiology; Female; Mitogen-Activated Protein Kinases/metabolism; Molecular Sequence Data; Neurons/physiology; Phylogeny; Receptors, Cell Surface/metabolism; Sequence Analysis, DNA; Signal Transduction; Smell/physiology; Vulva/embryology; Vulva/metabolism; ras Proteins/metabolism
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