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PMID:12632345
| Citation |
Abramson, LP, Stellmach, V, Doll, JA, Cornwell, M, Arensman, RM and Crawford, SE (2003) Wilms' tumor growth is suppressed by antiangiogenic pigment epithelium-derived factor in a xenograft model. J. Pediatr. Surg. 38:336-42; discussion 336-42 |
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| Abstract |
Pigment epithelium-derived factor (PEDF), a potent endogenous inhibitor of angiogenesis, is highly expressed in the kidney. The authors postulated that systemic administration of PEDF would decrease Wilms' tumor growth in a xenograft model, and increased renal vascularity would result in a mouse null for PEDF. |
| Links |
PubMed Online version:10.1053/jpsu.2003.50104 |
| Keywords |
Angiogenesis Inhibitors/therapeutic use; Animals; Eye Proteins; Humans; Kidney/blood supply; Kidney/secretion; Kidney Neoplasms/blood supply; Kidney Neoplasms/drug therapy; Kidney Neoplasms/pathology; Mice; Mice, Knockout; Mice, Nude; Mitotic Index; Neoplasm Transplantation; Neovascularization, Pathologic/drug therapy; Nerve Growth Factors; Proteins/genetics; Proteins/secretion; Proteins/therapeutic use; Recombinant Proteins/therapeutic use; Serpins/deficiency; Serpins/genetics; Serpins/secretion; Serpins/therapeutic use; Tumor Cells, Cultured/transplantation; Wilms Tumor/blood supply; Wilms Tumor/drug therapy; Wilms Tumor/pathology; Xenograft Model Antitumor Assays |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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