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PMID:12620118
| Citation |
Landis, GN, Bhole, D and Tower, J (2003) A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd and Cctl genes. Genome Biol. 4:R8 |
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| Abstract |
A P-type transposable element called PdL has been engineered with a doxycycline-inducible promoter directed out through the 3' end of the element. Insertion of PdL near the 5' end of a gene often yields doxycycline-dependent overexpression of that gene and a mutant phenotype. This functional genomics strategy allows for efficient screening of large numbers of genes for overexpression phenotypes. |
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| Keywords |
1-Phosphatidylinositol 4-Kinase/genetics; Animals; Choline-Phosphate Cytidylyltransferase/genetics; Contractile Proteins/genetics; DNA Transposable Elements/genetics; Doxycycline/pharmacology; Drosophila Proteins/genetics; Drosophila melanogaster/genetics; Gene Expression Regulation/drug effects; Longevity/genetics; Membrane Transport Proteins/genetics; Microfilament Proteins/genetics; Monosaccharide Transport Proteins; Mutagenesis, Insertional; Mutation; Vacuolar Proton-Translocating ATPases/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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