GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:12607127
| Citation |
Gesierich, A, Niroomand, F and Tiefenbacher, CP (2003) Role of human GTP cyclohydrolase I and its regulatory protein in tetrahydrobiopterin metabolism. Basic Res. Cardiol. 98:69-75 |
|---|---|
| Abstract |
GTP cyclohydrolase I (GTPCH I) catalyzes the de novo biosynthesis of tetrahydrobiopterin (BH(4)), an essential cofactor of NO-synthase. The enzyme underlies negative feedback regulation by the end product BH(4). This feedback inhibition is mediated through complex formation with the GTP cyclohydrolase I feedback regulatory protein (GFRP). To further classify the mechanism involved in the regulation of BH(4) synthesis, we measured expression of GTPCH I and GFRP in different human tissues. Furthermore, we looked for the influence of phenylalanine that is known to reverse BH(4)-mediated feedback inhibition of GTPCH I, and of immunostimulation with interferon gamma on the expression of GTPCH I and GFRP. |
| Links |
PubMed Online version:10.1007/s00395-003-0394-y |
| Keywords |
Antiviral Agents/pharmacology; Biopterin/analogs & derivatives; Biopterin/metabolism; Blotting, Northern; Cells, Cultured; Endothelium, Vascular/drug effects; Endothelium, Vascular/metabolism; GTP Cyclohydrolase/drug effects; GTP Cyclohydrolase/metabolism; Gene Expression Regulation; Humans; Interferon-gamma/pharmacology; Intracellular Signaling Peptides and Proteins; Phenylalanine/pharmacology; Proteins/drug effects; Proteins/metabolism; RNA, Messenger/analysis; Reverse Transcriptase Polymerase Chain Reaction; Umbilical Veins/cytology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
