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PMID:12456012

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Citation

Anjard, C, Loomis, WF and Dictyostelium Sequencing Consortium (2002) Evolutionary analyses of ABC transporters of Dictyostelium discoideum. Eukaryotic Cell 1:643-52

Abstract

The ABC superfamily of genes is one of the largest in the genomes of both bacteria and eukaryotes. The proteins encoded by these genes all carry a characteristic 200- to 250-amino-acid ATP-binding cassette that gives them their family name. In bacteria they are mostly involved in nutrient import, while in eukaryotes many are involved in export. Seven different families have been defined in eukaryotes based on sequence homology, domain topology, and function. While only 6 ABC genes in Dictyostelium discoideum have been studied in detail previously, sequences from the well-advanced Dictyostelium genome project have allowed us to recognize 68 members of this superfamily. They have been classified and compared to animal, plant, and fungal orthologs in order to gain some insight into the evolution of this superfamily. It appears that many of the genes inferred to have been present in the ancestor of the crown organisms duplicated extensively in some but not all phyla, while others were lost in one lineage or the other.

Links

PubMed PMC117992

Keywords

ATP-Binding Cassette Transporters/chemistry; ATP-Binding Cassette Transporters/classification; ATP-Binding Cassette Transporters/genetics; Amino Acid Sequence; Animals; Dictyostelium/genetics; Evolution, Molecular; Genes, Protozoan; Models, Genetic; Molecular Sequence Data; Multigene Family; Phylogeny; Protein Structure, Tertiary; Protozoan Proteins/chemistry; Protozoan Proteins/classification; Protozoan Proteins/genetics

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


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References

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