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PMID:12407145
| Citation |
Wu, BX, Chen, Y, Chen, Y, Fan, J, Rohrer, B, Crouch, RK and Ma, JX (2002) Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE. Invest. Ophthalmol. Vis. Sci. 43:3365-72 |
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| Abstract |
In the photic visual cycle, retinal G protein-coupled receptor (RGR) isomerizes all-trans retinal to 11-cis retinal in the retinal pigment epithelium (RPE) after illumination. It is unclear, however, how all-trans retinal, the substrate for RGR, is generated in the RPE, because no all-trans retinol dehydrogenase (atRDH) has been identified in the RPE. This study was conducted to identify the atRDH that generates all-trans retinal in the RPE. |
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| Keywords |
Alcohol Oxidoreductases/genetics; Alcohol Oxidoreductases/metabolism; Amino Acid Sequence; Animals; Blotting, Northern; COS Cells; Cattle; Cloning, Molecular; Expressed Sequence Tags; Humans; Immunoenzyme Techniques; In Situ Hybridization; Mice; Molecular Sequence Data; Pigment Epithelium of Eye/enzymology; RNA, Messenger/metabolism; Retinaldehyde/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Transfection; Vitamin A/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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