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PMID:12226503
| Citation |
Kliebenstein, DJ, Lim, JE, Landry, LG and Last, RL (2002) Arabidopsis UVR8 regulates ultraviolet-B signal transduction and tolerance and contains sequence similarity to human regulator of chromatin condensation 1. Plant Physiol. 130:234-43 |
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| Abstract |
To further our understanding of how plants defend against the harmful effects of ultraviolet (UV) light, we characterized an Arabidopsis mutant hypersensitive to UV-B. This mutant, UV resistance locus 8-1 (uvr8-1), contains a single recessive mutation at the bottom of chromosome 5. Fine-scale mapping localized uvr8-1 to a 21-kb locus containing five predicted open reading frames. Sequencing of this entire region revealed that the uvr8-1 allele contains a 15-nucleotide deletion in a gene similar to the human guanine nucleotide exchange factor regulator of chromatin condensation 1. This mutation reduces the UV-B-mediated induction of flavonoids and blocks chalcone synthase mRNA and protein induction. In contrast, uvr8-1 has enhanced induction of PR1 and PR5 proteins in response to UV-B, an indication of increased UV-B injury. These results suggest that UVR8 acts in a UV-B signal transduction pathway leading to induction of flavonoid biosynthesis. |
| Links |
PubMed PMC166556 Online version:10.1104/pp.005041 |
| Keywords |
Acyltransferases/metabolism; Adaptation, Physiological/physiology; Alleles; Arabidopsis/genetics; Arabidopsis/physiology; Arabidopsis/radiation effects; Arabidopsis Proteins/genetics; Arabidopsis Proteins/metabolism; Arabidopsis Proteins/physiology; Arabidopsis Proteins/radiation effects; Cell Cycle Proteins; Chromosome Mapping; Flavonoids/biosynthesis; Gene Expression Regulation, Plant/radiation effects; Genetic Complementation Test; Guanine Nucleotide Exchange Factors/genetics; Humans; Molecular Sequence Data; Mutation; Nuclear Proteins; Phenylpropionates/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; Sequence Analysis, DNA; Sequence Deletion; Signal Transduction/physiology; Ultraviolet Rays |
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Significance
Annotations
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