GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:12142008
| Citation |
Skaer, N, Pistillo, D, Gibert, JM, Lio, P, Wülbeck, C and Simpson, P (2002) Gene duplication at the achaete-scute complex and morphological complexity of the peripheral nervous system in Diptera. Trends Genet. 18:399-405 |
|---|---|
| Abstract |
The number of achaete-scute genes increased during insect evolution, particularly in the Diptera lineage. Sequence comparison indicates that the four achaete-scute genes of Drosophila result from three independent duplication events. After duplication, the new genes acquired individual expression patterns but, in Drosophila, their products can compensate for one another, which raises the question: why retain all four genes? The complexity of the spatial expression of these genes on the notum increased in the lineage leading to the higher Diptera, allowing the development of stereotyped bristle patterns. This probably coincided in time with gene duplication events, raising the possibility that an increase in gene copy number might have provided the flexibility necessary for more complex transcriptional regulation. |
| Links | |
| Keywords |
Amino Acid Sequence; Animals; Basic Helix-Loop-Helix Transcription Factors; DNA-Binding Proteins/genetics; Diptera/genetics; Drosophila Proteins; Evolution, Molecular; Gene Dosage; Gene Duplication; Molecular Sequence Data; Peripheral Nervous System/anatomy & histology; Phylogeny; Promoter Regions, Genetic; Sequence Alignment; Transcription Factors/genetics |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
