GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:12097474
| Citation |
Muir-Robinson, G, Hwang, BJ and Feller, MB (2002) Retinogeniculate axons undergo eye-specific segregation in the absence of eye-specific layers. J. Neurosci. 22:5259-64 |
|---|---|
| Abstract |
Spontaneous retinal activity mediated by cholinergic transmission regulates the segregation of retinal ganglion cell axons in the lateral geniculate nucleus of the thalamus into eye-specific layers. The details of how the layers form are unknown. Mice lacking the beta2 subunit of the neuronal nicotinic acetylcholine receptor lack ACh-mediated waves and as a result, do not form eye-specific layers at any stage of development. However, during the second postnatal week, beta2-/- mice have glutamate-mediated waves. Here we show that after the first postnatal week, even in the absence of layers, retinothalamic axons segregate into an unlayered, patchy distribution of eye-specific regions. These results indicate that spontaneous neural activity may independently regulate eye-specific segregation and the formation of layers at the developing retinothalamic projection. |
| Links | |
| Keywords |
Animals; Axons/ultrastructure; Geniculate Bodies/cytology; Geniculate Bodies/growth & development; Kinetics; Mice; Mice, Knockout; Receptors, Glutamate/metabolism; Receptors, Nicotinic/genetics; Retina/cytology; Retina/growth & development; Retinal Ganglion Cells/cytology; Visual Pathways |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
