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de Caestecker, MP, Bottomley, M, Bhattacharyya, S, Payne, TL, Roberts, AB and Yelick, PC (2002) The novel type I serine-threonine kinase receptor Alk8 binds TGF-beta in the presence of TGF-betaRII. Biochem. Biophys. Res. Commun. 293:1556-65
The TGF-beta superfamily consists of an array of ligands including BMP, TGF-beta, activin, and nodal subfamilies. The extensive range of biological effects elicited by TGF-beta family signaling is due in part to the large numbers and promiscuity of types I and II TGF-beta family member receptors. Alk8 is a novel type I TGF-beta family member receptor first identified in zebrafish [Dev. Dyn. 211 (4) (1998) 352], which participates in BMP signaling pathways [Development 128 (6) (2001) 849; Development 128 (6) (2001) 859; Mech. Dev. 100 (2) (2001) 275; J. Dent. Res. 80 (11) (2001) 1968]. Here we report that Alk8 also forms active signaling complexes with TGF-beta in the presence of TGF-betaRII. These results expand the signaling repertoire of zAlk8 by demonstrating an ability to participate in two distinct TGF-beta subfamily signaling pathways.
Activin Receptors, Type I; Amino Acid Sequence; Animals; Blotting, Northern; Blotting, Western; Bone Morphogenetic Proteins/metabolism; Cell Line; Cross-Linking Reagents/pharmacology; Humans; In Situ Hybridization; Ligands; Luciferases/metabolism; Mice; Molecular Sequence Data; Mutation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Protein-Serine-Threonine Kinases; Receptors, Transforming Growth Factor beta/chemistry; Receptors, Transforming Growth Factor beta/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tissue Distribution; Transforming Growth Factor beta/metabolism; Zebrafish; Zebrafish Proteins/chemistry; Zebrafish Proteins/metabolism
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