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PMID:12015966
| Citation |
Antoshechkin, I and Han, M (2002) The C. elegans evl-20 gene is a homolog of the small GTPase ARL2 and regulates cytoskeleton dynamics during cytokinesis and morphogenesis. Dev. Cell 2:579-91 |
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| Abstract |
The in vivo functions of ARF-like members of the Ras superfamily of GTPases are relatively unexplored. Here we describe the analysis of C. elegans evl-20 gene that encodes a functional homolog of human ARL2. Elimination of evl-20 function results in abnormal vulval, gonad, and male tail development and disrupts embryonic proliferation, hypodermal enclosure, and elongation. Loss of evl-20 function causes specific defects in the microtubule cytoskeleton, which is the likely molecular basis for the observed defects. EVL-20 is closely associated with both the cell cortex and astral microtubules, suggesting that it may directly interact with microtubule structures at those locations. Our data indicate that EVL-20 functions in the cytoplasm and at the plasma membrane to regulate cytoskeletal dynamics during cytokinesis and morphogenesis. |
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| Keywords |
Amino Acid Sequence; Animals; Base Sequence; Caenorhabditis elegans/cytology; Caenorhabditis elegans/genetics; Caenorhabditis elegans/growth & development; Caenorhabditis elegans Proteins/genetics; Cell Division/genetics; Cytoskeleton/physiology; DNA, Helminth/genetics; Female; GTP-Binding Proteins/genetics; Gene Expression Regulation, Developmental; Genes, Helminth; Gonads/growth & development; Humans; Male; Molecular Sequence Data; Mutation; Phenotype; Sequence Homology, Amino Acid; Tail/growth & development; Vulva/growth & development |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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