PMID:11955448

Citation	Lu, QR, Sun, T, Zhu, Z, Ma, N, Garcia, M, Stiles, CD and Rowitch, DH (2002) Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell 109:75-86
Abstract	The oligodendrocyte lineage genes Olig1 and Olig2 encode related bHLH proteins that are coexpressed in neural progenitors. Targeted disruption of these two genes sheds light on the ontogeny of oligodendroglia and genetic requirements for their development from multipotent CNS progenitors. Olig2 is required for oligodendrocyte and motor neuron specification in the spinal cord. Olig1 has roles in development and maturation of oligodendrocytes, evident especially within the brain. Both Olig genes contribute to neural pattern formation. Neither Olig gene is required for astrocytes. These findings, together with fate mapping analysis of Olig-expressing cells, indicate that oligodendrocytes are derived from Olig-specified progenitors that give rise also to neurons.
Links	PubMed
Keywords	Animals; Astrocytes/cytology; Astrocytes/metabolism; Basic Helix-Loop-Helix Transcription Factors; Body Patterning/genetics; Cell Differentiation/genetics; Cell Lineage/genetics; DNA-Binding Proteins; Female; Male; Mice; Mice, Knockout; Motor Neurons/cytology; Motor Neurons/metabolism; Mutation/physiology; Nerve Tissue Proteins/deficiency; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Oligodendroglia/cytology; Oligodendroglia/metabolism; Rhombencephalon/cytology; Rhombencephalon/embryology; Rhombencephalon/metabolism; Spinal Cord/cytology; Spinal Cord/embryology; Spinal Cord/metabolism; Stem Cells/cytology; Stem Cells/metabolism
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Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
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