PMID:11935029

Citation	Teder, P, Vandivier, RW, Jiang, D, Liang, J, Cohn, L, Puré, E, Henson, PM and Noble, PW (2002) Resolution of lung inflammation by CD44. Science 296:155-8
Abstract	Successful repair after tissue injury and inflammation requires resolution of the inflammatory response and removal of extracellular matrix breakdown products. We have examined whether the cell-surface adhesion molecule and hyaluronan receptor CD44 plays a role in resolving lung inflammation. CD44-deficient mice succumb to unremitting inflammation following noninfectious lung injury, characterized by impaired clearance of apoptotic neutrophils, persistent accumulation of hyaluronan fragments at the site of tissue injury, and impaired activation of transforming growth factor-beta1. This phenotype was partially reversed by reconstitution with CD44+ cells, thus demonstrating a critical role for this receptor in resolving lung inflammation.
Links	PubMed Online version:10.1126/science.1069659
Keywords	Animals; Antigens, CD44/physiology; Apoptosis; Bleomycin; Bone Marrow Transplantation; Bronchoalveolar Lavage Fluid/chemistry; Bronchoalveolar Lavage Fluid/cytology; Cell Count; Chemokines/genetics; Chemokines/metabolism; Chimera; Humans; Hyaluronic Acid/analysis; Hyaluronic Acid/metabolism; Lung/immunology; Lung/metabolism; Lung/pathology; Lung Diseases, Interstitial/immunology; Lung Diseases, Interstitial/metabolism; Lung Diseases, Interstitial/pathology; Macrophages, Alveolar/physiology; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Neutrophils; Phagocytosis; Phenotype; Pulmonary Alveoli/immunology; Pulmonary Alveoli/metabolism; Pulmonary Alveoli/pathology; RNA, Messenger/genetics; RNA, Messenger/metabolism; Transforming Growth Factor beta/metabolism; Transforming Growth Factor beta1
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