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PMID:11877381
| Citation |
Soto, MC, Qadota, H, Kasuya, K, Inoue, M, Tsuboi, D, Mello, CC and Kaibuchi, K (2002) The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans. Genes Dev. 16:620-32 |
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| Abstract |
During body morphogenesis precisely coordinated cell movements and cell shape changes organize the newly differentiated cells of an embryo into functional tissues. Here we describe two genes, gex-2 and gex-3, whose activities are necessary for initial steps of body morphogenesis in Caenorhabditis elegans. In the absence of gex-2 and gex-3 activities, cells differentiate properly but fail to become organized. The external hypodermal cells fail to spread over and enclose the embryo and instead cluster on the dorsal side. Postembryonically gex-3 activity is required for egg laying and for proper morphogenesis of the gonad. GEX-2 and GEX-3 proteins colocalize to cell boundaries and appear to directly interact. GEX-2 and GEX-3 are highly conserved, with vertebrate homologs implicated in binding the small GTPase Rac and a GEX-3 Drosophila homolog, HEM2/NAP1/KETTE, that interacts genetically with Rac pathway mutants. Our findings suggest that GEX-2 and GEX-3 may function at cell boundaries to regulate cell migrations and cell shape changes required for proper morphogenesis and development. |
| Links |
PubMed PMC155352 Online version:10.1101/gad.955702 |
| Keywords |
Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Caenorhabditis elegans/cytology; Caenorhabditis elegans/growth & development; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/isolation & purification; Caenorhabditis elegans Proteins/metabolism; Carrier Proteins/genetics; Cell Compartmentation; Cell Movement; Conserved Sequence; Drosophila Proteins; Genes, Helminth; Molecular Sequence Data; Morphogenesis; Oviposition/genetics; Sequence Homology, Amino Acid; rac GTP-Binding Proteins/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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