PMID:11738032

Citation	Wang, ZW, Saifee, O, Nonet, ML and Salkoff, L (2001) SLO-1 potassium channels control quantal content of neurotransmitter release at the C. elegans neuromuscular junction. Neuron 32:867-81
Abstract	Six mutants of SLO-1, a large-conductance, Ca(2+)-activated K(+) channel of C. elegans, were obtained in a genetic screen for regulators of neurotransmitter release. Mutants were isolated by their ability to suppress lethargy of an unc-64 syntaxin mutant that restricts neurotransmitter release. We measured evoked postsynaptic currents at the neuromuscular junction in both wild-type and mutants and observed that the removal of SLO-1 greatly increased quantal content primarily by increasing duration of release. The selective isolation of slo-1 as the only ion channel mutant derived from a whole genomic screen to detect regulators of neurotransmitter release suggests that SLO-1 plays an important, if not unique, role in regulating neurotransmitter release.
Links	PubMed
Keywords	Amino Acid Sequence; Animals; Caenorhabditis elegans/genetics; Caenorhabditis elegans/metabolism; Caenorhabditis elegans Proteins; Excitatory Postsynaptic Potentials/physiology; Large-Conductance Calcium-Activated Potassium Channels; Molecular Sequence Data; Mutation/genetics; Neuromuscular Junction/genetics; Neuromuscular Junction/metabolism; Neuromuscular Junction/secretion; Neurotransmitter Agents/genetics; Neurotransmitter Agents/metabolism; Neurotransmitter Agents/secretion; Potassium Channels/physiology; Potassium Channels, Calcium-Activated/genetics; Potassium Channels, Calcium-Activated/metabolism; Potassium Channels, Calcium-Activated/physiology; Presynaptic Terminals/metabolism; Presynaptic Terminals/secretion; Xenopus
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