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PMID:11581314
| Citation |
Yu, H, Leitenberg, D, Li, B and Flavell, RA (2001) Deficiency of small GTPase Rac2 affects T cell activation. J. Exp. Med. 194:915-26 |
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| Abstract |
Rac2 is a hematopoietic-specific GTPase acting as a molecular switch to mediate both transcriptional activation and cell morphological changes. We have examined the effect of Rac2 deficiency during T cell activation. In Rac2(-/-) T cells, proliferation was reduced upon stimulation with either plate-bound anti-CD3 or T cell receptor-specific antigen. This defect is accompanied with decreased activation of mitogen activated protein kinase extracellular signal-regulated kinase (ERK)1/2 and p38, and reduced Ca(2)+ mobilization. TCR stimulation-induced actin polymerization is also reduced. In addition, anti-CD3 cross-linking-induced T cell capping is reduced compared with wild-type T cells. These results indicate that Rac2 is important in mediating both transcriptional and cytoskeletal changes during T cell activation. The phenotypic similarity of Rac2(-/-) to Vav(-/-) cells implicates Rac2 as a downstream mediator of Vav signaling. |
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| Keywords |
Animals; Antigens, CD3/immunology; Calcium Signaling; Cell Cycle Proteins; Enzyme Activation; Lymphocyte Activation/immunology; Mice; Mice, Mutant Strains; Mice, Transgenic; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases/metabolism; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-vav; Receptors, Antigen, T-Cell/metabolism; T-Lymphocytes/immunology; p38 Mitogen-Activated Protein Kinases; rac GTP-Binding Proteins/deficiency |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0042129: regulation of T cell proliferation |
ECO:0000315: |
P |
Fig 2B shows a lower level of t cell proliferation in Rac2 knock out mice compared to the wild type mice. |
complete | ||||
|
involved_in |
GO:0042129: regulation of T cell proliferation |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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