PMID:11572991

Citation	Gaxiola, RA, Li, J, Undurraga, S, Dang, LM, Allen, GJ, Alper, SL and Fink, GR (2001) Drought- and salt-tolerant plants result from overexpression of the AVP1 H+-pump. Proc. Natl. Acad. Sci. U.S.A. 98:11444-9
Abstract	Transgenic plants overexpressing the vacuolar H(+)-pyrophosphatase are much more resistant to high concentrations of NaCl and to water deprivation than the isogenic wild-type strains. These transgenic plants accumulate more Na(+) and K(+) in their leaf tissue than the wild type. Moreover, direct measurements on isolated vacuolar membrane vesicles derived from the AVP1 transgenic plants and from wild type demonstrate that the vesicles from the transgenic plants have enhanced cation uptake. The phenotypes of the AVP1 transgenic plants suggest that increasing the vacuolar proton gradient results in increased solute accumulation and water retention. Presumably, sequestration of cations in the vacuole reduces their toxic effects. Genetically engineered drought- and salt-tolerant plants could provide an avenue to the reclamation of farmlands lost to agriculture because of salinity and a lack of rainfall.
Links	PubMed PMC58749 Online version:10.1073/pnas.191389398
Keywords	Abscisic Acid/pharmacology; Arabidopsis/drug effects; Arabidopsis/enzymology; Arabidopsis/genetics; Calcimycin/pharmacology; Calcium/metabolism; Calcium/pharmacology; Kinetics; Phenotype; Plants, Genetically Modified; Plasmids; Potassium/metabolism; Proton Pumps/genetics; Pyrophosphatases/genetics; Restriction Mapping; Sodium/metabolism; Solutions; Vacuoles/metabolism; Water/metabolism
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Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
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