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PMID:11527927
| Citation |
Sandbach, JM, Coscun, PE, Grossniklaus, HE, Kokoszka, JE, Newman, NJ and Wallace, DC (2001) Ocular pathology in mitochondrial superoxide dismutase (Sod2)-deficient mice. Invest. Ophthalmol. Vis. Sci. 42:2173-8 |
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| Abstract |
To characterize the pathologic features in retina, optic nerve, and extraocular muscle of mitochondrial superoxide dismutase (Sod2)-deficient mice, a model of increased mitochondrial production of reactive oxygen species. |
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| Keywords |
Animals; Free Radical Scavengers/therapeutic use; Metalloporphyrins/therapeutic use; Mice; Mice, Mutant Strains; Mitochondria/drug effects; Mitochondria/enzymology; Mitochondria/pathology; Mitochondria, Muscle/drug effects; Mitochondria, Muscle/enzymology; Mitochondria, Muscle/ultrastructure; Oculomotor Muscles/drug effects; Oculomotor Muscles/enzymology; Oculomotor Muscles/ultrastructure; Optic Nerve Diseases/enzymology; Optic Nerve Diseases/etiology; Optic Nerve Diseases/pathology; Optic Nerve Diseases/prevention & control; Oxidative Stress; Reactive Oxygen Species/metabolism; Retinal Diseases/enzymology; Retinal Diseases/etiology; Retinal Diseases/pathology; Retinal Diseases/prevention & control; Superoxide Dismutase/deficiency |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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