PMID:11509232

Citation	Reed, BH, Wilk, R and Lipshitz, HD (2001) Downregulation of Jun kinase signaling in the amnioserosa is essential for dorsal closure of the Drosophila embryo. Curr. Biol. 11:1098-108
Abstract	During Drosophila embryogenesis, Jun kinase (JNK) signaling has been shown to play a key role in regulating the morphogenetic process of dorsal closure, which also serves as a model for epithelial sheet fusion during wound repair. During dorsal closure the JNK signaling cascade in the dorsal-most (leading edge) cells of the epidermis activates the AP-1 transcription factor comprised of DJUN and DFOS that, in turn, upregulates the expression of the dpp gene. DPP is a secreted morphogen that signals lateral epidermal cells to elongate along the dorsoventral axis. The leading edge cells contact the peripheral cells of a monolayer extraembryonic epithelium, the amnioserosa, which lies on the dorsal side of the embryo. Focal complexes are present at the dorsal-most membrane of the leading edge cells, where they contact the amnioserosa.
Links	PubMed
Keywords	Amnion/embryology; Amnion/enzymology; Animals; Down-Regulation; Drosophila/embryology; Drosophila/enzymology; Drosophila/genetics; Drosophila Proteins; Epidermis/embryology; Epidermis/enzymology; Epithelium/embryology; Epithelium/enzymology; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases/genetics; Mitogen-Activated Protein Kinases/metabolism; Mutation; Nuclear Proteins/genetics; Proto-Oncogene Proteins c-fos/metabolism; Proto-Oncogene Proteins c-jun/metabolism; Signal Transduction; Subcellular Fractions/metabolism; Transcription Factor AP-1/metabolism; Transcription Factors/genetics
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Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
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