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PMID:11478795
| Citation |
Rodrigues-Lima, F, Josephs, M, Katan, M and Cassinat, B (2001) Sequence analysis identifies TTRAP, a protein that associates with CD40 and TNF receptor-associated factors, as a member of a superfamily of divalent cation-dependent phosphodiesterases. Biochem. Biophys. Res. Commun. 285:1274-9 |
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| Abstract |
CD40 is a member of the tumor necrosis factor (TNF) receptor family. CD40-mediated signal transduction involves the recruitment of several cytoplasmic proteins and induces expression of a large number of genes. TTRAP, a novel protein that interacts with the cytoplasmic domain of CD40 and with TNF-receptor associated factors (TRAFs), has been cloned and shown to inhibit nuclear factor-kappaB activation (NF-kappaB). By using various bioinformatics-based sequence and structure analyses of proteins involved in signaling by the TNF receptor family, we found that TTRAP is a member of a superfamily of Mg(2+)/Mn(2+)-dependent phosphodiesterases. More precisely, our results suggest that TTRAP is related to the human APE1, a Mg(2+)-dependent endonuclease. This potential novel function of TTRAP raises the intriguing possibility for a role of APE1-like DNA-repair endonucleases in TNF receptor family-mediated signaling and functions. |
| Links |
PubMed Online version:10.1006/bbrc.2001.5328 |
| Keywords |
Amino Acid Motifs/genetics; Animals; Antigens, CD40/metabolism; Carbon-Oxygen Lyases/genetics; Carrier Proteins/genetics; Carrier Proteins/metabolism; Conserved Sequence; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Databases, Factual; Deoxyribonuclease IV (Phage T4-Induced); Humans; Magnesium/metabolism; Manganese/metabolism; Mice; Multigene Family/genetics; Phosphoric Diester Hydrolases/genetics; Phosphoric Diester Hydrolases/metabolism; Rats; Sequence Alignment; Sequence Analysis, Protein; Sequence Homology, Amino Acid; Signal Transduction |
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Significance
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