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PMID:11326102
| Citation |
Kramer, SG, Kidd, T, Simpson, JH and Goodman, CS (2001) Switching repulsion to attraction: changing responses to slit during transition in mesoderm migration. Science 292:737-40 |
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| Abstract |
Slit is secreted by cells at the midline of the central nervous system, where it binds to Roundabout (Robo) receptors and functions as a potent repellent. We found that migrating mesodermal cells in vivo respond to Slit as both an attractant and a repellent and that Robo receptors are required for both functions. Mesoderm cells expressing Robo receptors initially migrate away from Slit at the midline. A few hours after migration, these same cells change their behavior and require Robo to extend toward Slit-expressing muscle attachment sites. Thus, Slit functions as a chemoattractant to provide specificity for muscle patterning. |
| Links |
PubMed Online version:10.1126/science.1058766 |
| Keywords |
Animals; Body Patterning; Cell Fusion; Cell Movement; Drosophila/embryology; Drosophila/genetics; Drosophila Proteins; Embryo, Nonmammalian/cytology; Embryo, Nonmammalian/metabolism; Epidermis/embryology; Epidermis/metabolism; Mesoderm/cytology; Mesoderm/metabolism; Microscopy, Confocal; Muscles/cytology; Muscles/embryology; Muscles/metabolism; Mutation; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Receptors, Immunologic/genetics; Receptors, Immunologic/metabolism; Signal Transduction; Stem Cells/metabolism; Stem Cells/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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