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PMID:11295559
| Citation |
Falke, JJ and Hazelbauer, GL (2001) Transmembrane signaling in bacterial chemoreceptors. Trends Biochem. Sci. 26:257-65 |
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| Abstract |
Bacterial chemoreceptors mediate chemotaxis by recognizing specific chemicals and regulating a noncovalently associated histidine kinase. Ligand binding to the external domain of the membrane-spanning receptor generates a transmembrane signal that modulates kinase activity inside the cell. This transmembrane signaling is being investigated by novel strategies, which have revealed a remarkably subtle conformational signal carried by a signaling helix that spans the entire length of the >350-A-long receptor. Multiple, independent lines of evidence indicate that, in the periplasmic and transmembrane domains, conformational signaling is a piston-type sliding of the signaling helix towards the cytoplasm. |
| Links | |
| Keywords |
Bacteria/metabolism; Bacterial Proteins; Cell Membrane/metabolism; Chemoreceptor Cells/metabolism; Signal Transduction |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0006935: chemotaxis |
ECO:0000021: |
P |
Figure 1. Hydrolysis of Phosphorylated CheY Phosphorylated CheY reversed flagellar rotation from CCW to CW. |
Missing: with/from | ||||
| GO:0006935 : chemotaxis |
ECO:0000021: |
EcoCyc:EG10146 EcoCyc:b1888
|
P |
Figure1. two-component signal transduction complex |
complete | |||
| GO:0006935 : chemotaxis |
ECO:0000021: |
P |
Fig. I. Components of the chemotaxis system in Escherichia coli. Pi acts as Response regulator producing global reduction in receptor demethylation. |
Missing: with/from | ||||
See also
References
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