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PMID:11286886
| Citation |
Nishino, T, Komori, K, Tsuchiya, D, Ishino, Y and Morikawa, K (2001) Crystal structure of the archaeal holliday junction resolvase Hjc and implications for DNA recognition. Structure 9:197-204 |
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| Abstract |
Homologous recombination is a crucial mechanism in determining genetic diversity and repairing damaged chromosomes. Holliday junction is the universal DNA intermediate whose interaction with proteins is one of the major events in the recombinational process. Hjc is an archaeal endonuclease, which specifically resolves the junction DNA to produce two separate recombinant DNA duplexes. The atomic structure of Hjc should clarify the mechanisms of the specific recognition with Holliday junction and the catalytic reaction. |
| Links | |
| Keywords |
Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; DNA, Archaeal/chemistry; Deoxyribonucleases, Type II Site-Specific/chemistry; Dimerization; Endodeoxyribonucleases/chemistry; Endodeoxyribonucleases/genetics; Holliday Junction Resolvases; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Protein Folding; Pyrococcus furiosus/chemistry; Sequence Alignment |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0048476: Holliday junction resolvase complex |
ECO:0000315: |
C |
Fig 7 |
complete | ||||
Notes
See also
References
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