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PMID:11212121
| Citation |
Sorba, G, Bertinaria, M, Di Stilo, A, Gasco, A, Scaltrito, MM, Brenciaglia, MI and Dubini, F (2001) Anti-Helicobacter pylori agents endowed with H2-antagonist properties. Bioorg. Med. Chem. Lett. 11:403-6 |
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| Abstract |
New anti-Helicobacter pylori (H. pylori) agents endowed with H2-antagonists properties were obtained by combining the lamtidine derived pharmacophoric group with the antibiotic calvatic acid. All the compounds were tested for their irreversible H2-antagonist properties and for their ability to inhibit 20 H. pylori strains, two of them metronidazole resistant. The most active derivative (compound 4) displayed antimicrobial activity similar to metronidazole. |
| Links | |
| Keywords |
Animals; Anti-Bacterial Agents/chemical synthesis; Anti-Bacterial Agents/chemistry; Anti-Bacterial Agents/pharmacology; Benzoates/chemistry; Benzoates/pharmacology; Binding, Competitive; Combinatorial Chemistry Techniques; Dose-Response Relationship, Drug; Drug Resistance; Guinea Pigs; Heart Atria/chemistry; Helicobacter pylori/drug effects; Histamine/metabolism; Histamine H2 Antagonists/chemical synthesis; Histamine H2 Antagonists/pharmacology; Metronidazole/pharmacology; Microbial Sensitivity Tests; Nitriles/chemistry; Nitriles/pharmacology; Piperidines/chemistry; Piperidines/pharmacology; Receptors, Histamine H2/metabolism; Structure-Activity Relationship; Triazoles/chemistry; Triazoles/pharmacology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:1901857: positive regulation of cellular respiration |
ECO:0000314: |
P |
complete | |||||
See also
References
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