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PMID:11208722
| Citation |
Boku, K, Ohno, T, Saeki, T, Hayashi, H, Hayashi, I, Katori, M, Murata, T, Narumiya, S, Saigenji, K and Majima, M (2001) Adaptive cytoprotection mediated by prostaglandin I(2) is attributable to sensitization of CRGP-containing sensory nerves. Gastroenterology 120:134-43 |
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| Abstract |
The phenomenon by which the gastric mucosa is protected in response to mild irritants has been called adaptive cytoprotection, a mechanism believed to be related to production of endogenous prostaglandins (PGs). We tested whether PGs generated by mild irritant prevent injury through the release of calcitonin gene-related peptide (CGRP) from the sensory nerves using prostanoid receptor-knockout mice. |
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| Keywords |
6-Ketoprostaglandin F1 alpha/metabolism; Adaptation, Physiological/drug effects; Anesthesia; Animals; Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Calcitonin Gene-Related Peptide/antagonists & inhibitors; Calcitonin Gene-Related Peptide/metabolism; Calcitonin Gene-Related Peptide/pharmacology; Central Nervous System Depressants/pharmacology; Dinoprostone/metabolism; Dinoprostone/pharmacology; Epoprostenol/metabolism; Ethanol/pharmacology; Gastric Mucosa/drug effects; Gastric Mucosa/innervation; Gastric Mucosa/metabolism; Indomethacin/pharmacology; Male; Mice; Mice, Knockout; Neurons, Afferent/metabolism; Peptide Fragments/antagonists & inhibitors; Peptide Fragments/metabolism; Peptide Fragments/pharmacology; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin/genetics; Sodium Chloride/pharmacology; Stomach Ulcer/chemically induced; Stomach Ulcer/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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