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PMID:11119620
| Citation |
Bohl, J, Hull, B and Vande Pol, SB (2001) Cooperative transformation and coexpression of bovine papillomavirus type 1 E5 and E7 proteins. J. Virol. 75:513-21 |
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| Abstract |
Productively infected bovine fibropapillomas were examined for bovine papillomavirus type 1 (BPV-1) E7 localization. BPV-1 E7 was observed in the cytoplasm of basal and lower spinous epithelial cells, coexpressed in the cytoplasm of basal cells with the E5 oncoprotein. E7 was also observed in nucleoli throughout the basal and spinous layers but not in the granular cell layer. Ectopic expression of E7 in cultured epithelial cells gave rise to localization similar to that seen in productive fibropapillomas, with cytoplasmic and nucleolar expression observed. Consistent with the coexpression of E7 and E5 in basal keratinocytes, BPV-1 E7 cooperated with E5 as well as E6 in an anchorage independence transformation assay. While E5 is expressed in both basal and superficial differentiating keratinocytes, BPV-1 E7 is only observed in basal and lower spinous epithelial cells. Therefore, BPV-1 E7 may serve to modulate the cellular response of basal epithelial cells to E5 expression. |
| Links |
PubMed PMC113944 Online version:10.1128/JVI.75.1.513-521.2001 |
| Keywords |
Animals; Cattle; Cell Transformation, Neoplastic; Immunohistochemistry; Mice; Oncogene Proteins, Viral/analysis; Oncogene Proteins, Viral/physiology; Papilloma/chemistry; Papilloma/virology; Rabbits; Transfection |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0019087: transformation of host cell by virus |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0019087: transformation of host cell by virus |
ECO:0000314: |
P |
Evidenced through western blot, shown in figure 1 |
complete | ||||
|
involved_in |
GO:0019087: transformation of host cell by virus |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0019087: transformation of host cell by virus |
ECO:0000314: |
P |
Figure 6 shows co-transforming actions of both E7, E6, and E5 |
complete | ||||
See also
References
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