GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:10949028
| Citation |
Hopper, NA, Lee, J and Sternberg, PW (2000) ARK-1 inhibits EGFR signaling in C. elegans. Mol. Cell 6:65-75 |
|---|---|
| Abstract |
A screen for synthetic enhancers of sli-1 identified ark-1 (forAck-related tyrosine kinase), a novel inhibitor of let-23 EGFR signaling in C. elegans. An ark-1 mutation synergizes with mutations in other negative regulators of let-23, resulting in increased RAS signaling. Genetic analysis suggests that ARK-1 acts upstream of RAS and is dependent upon SEM-5. ARK-1 inhibits LET-23-mediated ovulation, a RAS-independent function. ARK-1 physically interacts with SEM-5 in the yeast two-hybrid assay. We find that sem-5 also has a negative function in let-23-mediated ovulation and suggest that this negative function is mediated by the recruitment of inhibitors such as ARK-1. |
| Links | |
| Keywords |
Amino Acid Sequence; Animals; Caenorhabditis elegans/genetics; Caenorhabditis elegans/growth & development; Caenorhabditis elegans/metabolism; Caenorhabditis elegans Proteins; Cloning, Molecular; Female; Fertility/physiology; Genes, Helminth; Genes, Lethal; Genes, ras; Helminth Proteins/metabolism; Models, Biological; Molecular Sequence Data; Mutation; Ovulation/physiology; Protein-Tyrosine Kinases/genetics; Protein-Tyrosine Kinases/metabolism; Receptor, Epidermal Growth Factor/metabolism; Sequence Homology, Amino Acid; Signal Transduction; Two-Hybrid System Techniques; Vulva/growth & development |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
