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PMID:10913079
| Citation |
Ye, RW, Tao, W, Bedzyk, L, Young, T, Chen, M and Li, L (2000) Global gene expression profiles of Bacillus subtilis grown under anaerobic conditions. J. Bacteriol. 182:4458-65 |
|---|---|
| Abstract |
Bacillus subtilis can grow under anaerobic conditions, either with nitrate or nitrite as the electron acceptor or by fermentation. A DNA microarray containing 4,020 genes from this organism was constructed to explore anaerobic gene expression patterns on a genomic scale. When mRNA levels of aerobic and anaerobic cultures during exponential growth were compared, several hundred genes were observed to be induced or repressed under anaerobic conditions. These genes are involved in a variety of cell functions, including carbon metabolism, electron transport, iron uptake, antibiotic production, and stress response. Among the highly induced genes are not only those responsible for nitrate respiration and fermentation but also those of unknown function. Certain groups of genes were specifically regulated during anaerobic growth on nitrite, while others were primarily affected during fermentative growth, indicating a complex regulatory circuitry of anaerobic metabolism. |
| Links | |
| Keywords |
Aerobiosis; Anaerobiosis; Bacillus subtilis/genetics; Bacillus subtilis/growth & development; Bacillus subtilis/physiology; Electron Transport; Fermentation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Nitrates/metabolism; Nitrites/metabolism; Open Reading Frames; Polymerase Chain Reaction; RNA, Messenger/genetics; Transcription, Genetic |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0047605: acetolactate decarboxylase activity |
ECO:0000270: expression pattern evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0047605: acetolactate decarboxylase activity |
ECO:0000270: |
F |
Table 2. |
complete | ||||
| GO:0006811: ion transport |
ECO:0000270: |
P |
Figure 1. |
complete | ||||
|
involved_in |
GO:0006811: ion transport |
ECO:0000270: expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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