PMID:10896158

Citation	Sawin, ER, Ranganathan, R and Horvitz, HR (2000) C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway. Neuron 26:619-31
Abstract	Caenorhabditis elegans modulates its locomotory rate in response to its food, bacteria, in two ways. First, well-fed wild-type animals move more slowly in the presence of bacteria than in the absence of bacteria. This basal slowing response is mediated by a dopamine-containing neural circuit that senses a mechanical attribute of bacteria and may be an adaptive mechanism that increases the amount of time animals spend in the presence of food. Second, food-deprived wild-type animals, when transferred to bacteria, display a dramatically enhanced slowing response that ensures that the animals do not leave their newly encountered source of food. This experience-dependent response is mediated by serotonergic neurotransmission and is potentiated by fluoxetine (Prozac). The basal and enhanced slowing responses are distinct and separable neuromodulatory components of a genetically tractable paradigm of behavioral plasticity.
Links	PubMed
Keywords	Animals; Caenorhabditis elegans/physiology; Caenorhabditis elegans Proteins; Catalase/genetics; Dopamine/pharmacology; Dopamine/physiology; Environment; Escherichia coli/physiology; Fluoxetine/pharmacology; Food Deprivation/physiology; Fungal Proteins/genetics; Helminth Proteins/genetics; Mechanoreceptors/physiology; Mixed Function Oxygenases; Motor Activity/drug effects; Motor Activity/physiology; Mutation/physiology; Neurons/physiology; Serotonin/physiology; Serotonin Uptake Inhibitors/pharmacology; Time Factors; Trans-Activators/genetics
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