PMID:10811621

Citation	Aldon, D, Brito, B, Boucher, C and Genin, S (2000) A bacterial sensor of plant cell contact controls the transcriptional induction of Ralstonia solanacearum pathogenicity genes. EMBO J. 19:2304-14
Abstract	The hrp genes of the plant pathogen Ralstonia solanacearum are key pathogenicity determinants; they encode a type III protein secretion machinery involved in the secretion of mediators of the bacterium-plant interaction. These hrp genes are under the genetic control of the hrpB regulatory gene, expression of which is induced when bacteria are co-cultivated with plant cell suspensions. In this study, we used hrp-gfp transcriptional fusions to demonstrate that the expression of the hrpB and type III secretion genes is specifically induced in response to the bacterium-plant cell contact. This contact-dependent induction of hrpB gene expression requires the outer membrane protein PrhA, but not a functional type III secretion apparatus. Genetic evidence indicates that PrhA constitutes the first example of a bacterial receptor for a non-diffusible signal present in the plant cell wall and which triggers the transcriptional activation of bacterial virulence genes.
Links	PubMed PMC384368 Online version:10.1093/emboj/19.10.2304
Keywords	Arabidopsis/genetics; Arabidopsis/microbiology; Arabidopsis Proteins; Bacterial Proteins/genetics; Betaproteobacteria/pathogenicity; Betaproteobacteria/physiology; DNA-Binding Proteins; Gene Expression Regulation, Bacterial; Homeodomain Proteins/genetics; Plant Proteins/genetics; Repressor Proteins/genetics; Transcription Factors; Transcription, Genetic
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