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PMID:10704412
| Citation |
Smardon, A, Spoerke, JM, Stacey, SC, Klein, ME, Mackin, N and Maine, EM (2000) EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans. Curr. Biol. 10:169-78 |
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| Abstract |
Cell-fate determination requires that cells choose between alternative developmental pathways. For example, germ cells in the nematode worm Caenorhabditis elegans choose between mitotic and meiotic division, and between oogenesis and spermatogenesis. Germ-line mitosis depends on a somatic signal that is mediated by a Notch-type signaling pathway. The ego-1 gene was originally identified on the basis of genetic interactions with the receptor in this pathway and was also shown to be required for oogenesis. Here, we provide more insight into the role of ego-1 in germ-line development. |
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| Keywords |
Amino Acid Sequence; Animals; Caenorhabditis elegans/enzymology; Caenorhabditis elegans/genetics; Caenorhabditis elegans Proteins; Gametogenesis; Germ Cells; Male; Meiosis; Mitosis; Molecular Sequence Data; Mutagenesis; Phenotype; RNA Processing, Post-Transcriptional; RNA Replicase/genetics; RNA Replicase/physiology; Sequence Homology, Amino Acid |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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