PMID:10591209

Citation	Shin, MK, Levorse, JM, Ingram, RS and Tilghman, SM (1999) The temporal requirement for endothelin receptor-B signalling during neural crest development. Nature 402:496-501
Abstract	Endothelin receptor B (EDNRB) is a G-protein-coupled receptor with seven transmembrane domains which is required for the development of melanocytes and enteric neurons. Mice that are homozygous for a null mutation in the Ednrb gene are almost completely white and die as juveniles from megacolon. To determine when EDNRB signalling is required during embryogenesis, we have exploited the tetracycline-inducible system to generate strains of mice in which the endogenous Ednrb locus is under the control of the tetracycline-dependant transactivators tTa or rtTA. By using this system to express Ednrb at different stages of embryogenesis, we have determined that EDNRB is required during a restricted period of neural crest development between embryonic days 10 and 12.5. Moreover, our results imply that EDNRB is required for the migration of both melanoblasts and enteric neuroblasts.
Links	PubMed Online version:10.1038/990040
Keywords	Animals; Cecum/cytology; Cecum/embryology; Cell Differentiation/genetics; Cell Movement/physiology; Colon/cytology; Colon/embryology; Doxycycline/pharmacology; Gene Expression Regulation, Developmental/drug effects; Melanocytes/cytology; Mice; Mice, Inbred C57BL; Neural Crest/metabolism; Neurons/cytology; Receptor, Endothelin B; Receptors, Endothelin/genetics; Receptors, Endothelin/metabolism; Receptors, Endothelin/physiology; Signal Transduction; Tetracycline/pharmacology; Trans-Activators/metabolism
edit table

Annotations

Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
edit table

References

See Help:References for how to manage references in GONUTS.