GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:10561496
| Citation |
Gieseler, K, Abdel-Dayem, M and Ségalat, L (1999) In vitro interactions of Caenorhabditis elegans dystrophin with dystrobrevin and syntrophin. FEBS Lett. 461:59-62 |
|---|---|
| Abstract |
Dystrophin, the product of the gene mutated in Duchenne muscular dystrophy (DMD) is bound by its C-terminus to a protein complex including the related protein dystrobrevin. Both proteins contain a putative coiled-coil domain consisting of two alpha-helices. It has been reported that the two proteins bind to each other by the first one of the two alpha-helices. We have revisited this question using the Caenorhabditis elegans homologs of dystrophin and dystrobrevin. In vitro interaction occurs through the more conserved second helix. We propose a new model of dystrophin interactions with associated proteins. |
| Links | |
| Keywords |
Amino Acid Sequence; Animals; Caenorhabditis elegans/chemistry; Caenorhabditis elegans Proteins; Dystrophin/chemistry; Dystrophin/metabolism; Dystrophin-Associated Proteins; Glutathione Transferase/metabolism; Humans; Membrane Proteins/chemistry; Membrane Proteins/metabolism; Models, Biological; Molecular Sequence Data; Muscle Proteins/chemistry; Muscle Proteins/metabolism; Nerve Tissue Proteins; Neuropeptides/chemistry; Neuropeptides/metabolism; Protein Binding; Protein Conformation; Recombinant Fusion Proteins/metabolism; Sequence Homology, Amino Acid |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
