PMID:10383984

Citation	Koide, A, Perego, M and Hoch, JA (1999) ScoC regulates peptide transport and sporulation initiation in Bacillus subtilis. J. Bacteriol. 181:4114-7
Abstract	Oligopeptides are transported into Bacillus subtilis by two ABC transport systems, App and Opp. Transcription of the operon encoding the Opp system was found to occur during exponential growth, whereas the app operon was induced at the onset of stationary phase. Transcription of both operons was completely curtailed by overproduction of the ScoC regulator from a multicopy plasmid and was enhanced in strains with the scoC locus deleted. ScoC, a member of the MarR family of transcription regulators, is known from previous studies to be a negative regulator of sporulation and of protease production that acts by binding directly to the promoters of the genes it regulates. Since peptide transport is essential for inactivation of the negative regulation of sporulation by Rap phosphatases, the control of ScoC transcription repression activity plays a crucial role in the initiation of sporulation.
Links	PubMed PMC93906
Keywords	ATP-Binding Cassette Transporters/biosynthesis; Bacillus subtilis/physiology; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Biological Transport; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Gene Deletion; Gene Expression Regulation, Bacterial; Genes, Reporter; Oligopeptides/metabolism; Spores, Bacterial; Transcription, Genetic
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Significance

Gene product	Qualifier	GO Term	Evidence Code	Aspect	Notes	Status
BACSU:HPR	involved_in	GO:0006355: regulation of transcription, DNA-templated	ECO:0000315: mutant phenotype evidence used in manual assertion	P	Seeded From UniProt	complete
BACSU:HPR		GO:0006355: regulation of transcription, DNA-dependent	ECO:0000315:	P	Figure 2	complete CACAO 2861

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