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PMID:10366590
| Citation |
Wen, C and Greenwald, I (1999) p24 proteins and quality control of LIN-12 and GLP-1 trafficking in Caenorhabditis elegans. J. Cell Biol. 145:1165-75 |
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| Abstract |
Mutations in the Caenorhabditis elegans sel-9 gene elevate the activity of lin-12 and glp-1, which encode members of the LIN-12/NOTCH family of receptors. Sequence analysis indicates SEL-9 is one of several C. elegans p24 proteins. Allele-specific genetic interactions suggest that reducing sel-9 activity increases the activity of mutations altering the extracellular domains of LIN-12 or GLP-1. Reducing sel-9 activity restores the trafficking to the plasma membrane of a mutant GLP-1 protein that would otherwise accumulate within the cell. Our results suggest a role for SEL-9 and other p24 proteins in the negative regulation of transport of LIN-12 and GLP-1 to the cell surface, and favor a role for p24 proteins in a quality control mechanism for endoplasmic reticulum-Golgi transport. |
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| Keywords |
Alleles; Amino Acid Sequence; Animals; Biological Transport; Caenorhabditis elegans/cytology; Caenorhabditis elegans/genetics; Caenorhabditis elegans/metabolism; Caenorhabditis elegans Proteins; Cell Lineage; Cell Membrane/metabolism; Cloning, Molecular; Disorders of Sex Development; Endoplasmic Reticulum/chemistry; Endoplasmic Reticulum/metabolism; Genes, Helminth/genetics; Genes, Helminth/physiology; Genes, Lethal/genetics; Golgi Apparatus/chemistry; Golgi Apparatus/metabolism; Helminth Proteins/chemistry; Helminth Proteins/genetics; Helminth Proteins/metabolism; Helminth Proteins/physiology; Membrane Glycoproteins/genetics; Membrane Glycoproteins/metabolism; Membrane Proteins/genetics; Membrane Proteins/metabolism; Molecular Sequence Data; Mutation; Phenotype; Sequence Homology, Amino Acid; Stem Cells/cytology; Suppression, Genetic/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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