GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:10072380
| Citation |
Bloecher, A and Tatchell, K (1999) Defects in Saccharomyces cerevisiae protein phosphatase type I activate the spindle/kinetochore checkpoint. Genes Dev. 13:517-22 |
|---|---|
| Abstract |
A conditional allele of type 1 protein phosphatase (glc7-129) in Saccharomyces cerevisiae causes first cycle arrest in G2/M, characterized by cells with a short spindle and high H1 kinase activity. Point-of-execution experiments indicate Glc7p function is required in G2/M just before anaphase for the completion of mitosis. Loss of the spindle/kinetochore checkpoint in glc7-129 cells abolishes the G2/M cell cycle arrest with a concomitant increase in chromosome loss and reduced viability. These results support a role for Glc7p in regulating kinetochore attachment to the spindle, an event monitored by the spindle/kinetochore checkpoint. |
| Links | |
| Keywords |
Chromosomes, Fungal; Fungal Proteins/genetics; Fungal Proteins/physiology; G2 Phase; Kinetochores/physiology; Mitosis; Mitotic Spindle Apparatus/physiology; Phosphoprotein Phosphatases/genetics; Phosphoprotein Phosphatases/physiology; Saccharomyces cerevisiae/enzymology; Saccharomyces cerevisiae/genetics; Signal Transduction |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
