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PMID:10021351
| Citation |
Morita, K, Chow, KL and Ueno, N (1999) Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family. Development 126:1337-47 |
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| Abstract |
We have identified a new member of the TGF-beta superfamily, CET-1, from Caenorhabditis elegans, which is expressed in the ventral nerve cord and other neurons. cet-1 null mutants have shortened bodies and male tail abnormal phenotype resembling sma mutants, suggesting cet-1, sma-2, sma-3 and sma-4 share a common pathway. Overexpression experiments demonstrated that cet-1 function requires wild-type sma genes. Interestingly, CET-1 appears to affect body length in a dose-dependent manner. Heterozygotes for cet-1 displayed body lengths ranging between null mutant and wild type, and overexpression of CET-1 in wild-type worms elongated body length close to lon mutants. In male sensory ray patterning, lack of cet-1 function results in ray fusions. Epistasis analysis revealed that mab-21 lies downstream and is negatively regulated by the cet-1/sma pathway in the male tail. Our results show that cet-1 controls diverse biological processes during C. elegans development probably through different target genes. |
| Links | |
| Keywords |
Amino Acid Sequence; Animals; Base Sequence; Body Constitution/physiology; Caenorhabditis elegans/genetics; Caenorhabditis elegans/growth & development; Caenorhabditis elegans Proteins; DNA, Complementary/genetics; Epistasis, Genetic; Genes, Helminth; Helminth Proteins/genetics; Helminth Proteins/metabolism; Ligands; Male; Models, Biological; Molecular Sequence Data; Mutagenesis, Insertional; Nerve Tissue; Neurons; Neuropeptides; Phenotype; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Signal Transduction; Tail/abnormalities; Tissue Distribution; Transforming Growth Factor beta/genetics; Transforming Growth Factor beta/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0035121: growth factor activity |
ECO:0000315: |
F |
Figure 3. The cet-1 null mutation in Caenorhabditis elegans results in distortion of tail development and structure and fusion of multiple tails of the nematode. Cet-1 is necessary for proper development of C. elegans tails. |
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See also
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