PLAFA:Q9U738

Species (Taxon ID)	Plasmodium falciparum. (5833)
Gene Name(s)	dhfs-fpgs (ECO:0000313 with EMBL:AAD43960.2)
Protein Name(s)	Dihydrofolate synthase/folylpolyglutamate synthase (ECO:0000313 with EMBL:AAD43960.2)
External Links
UniProt	Q9U738
EMBL	AF161264
SMR	Q9U738
eggNOG	KOG2525 COG0285
BRENDA	6.3.2.12
GO	GO:0005524 GO:0004326
Gene3D	3.40.1190.10 3.90.190.20
InterPro	IPR001645 IPR018109 IPR036565 IPR036615 IPR013221
PANTHER	PTHR11136
Pfam	PF08245
SUPFAM	SSF53244 SSF53623
TIGRFAMs	TIGR01499
PROSITE	PS01012

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0009396	folic acid-containing compound biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001645 InterPro:IPR018109	P		Seeded From UniProt
enables	GO:0016874	ligase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR036615	F		Seeded From UniProt
involved_in	GO:0009058	biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013221 InterPro:IPR036565 InterPro:IPR036615	P		Seeded From UniProt
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001645 InterPro:IPR013221 InterPro:IPR018109 InterPro:IPR036565 InterPro:IPR036615	F		Seeded From UniProt
enables	GO:0004326	tetrahydrofolylpolyglutamate synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001645 InterPro:IPR018109	F		Seeded From UniProt
involved_in	GO:0046901	tetrahydrofolylpolyglutamate biosynthetic process	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004326	P		Seeded From UniProt
involved_in	GO:0009396	folic acid-containing compound biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001645 InterPro:IPR018109	P		Seeded From UniProt
enables	GO:0016874	ligase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR036615	F		Seeded From UniProt
involved_in	GO:0009058	biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013221 InterPro:IPR036565 InterPro:IPR036615	P		Seeded From UniProt
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001645 InterPro:IPR013221 InterPro:IPR018109 InterPro:IPR036565 InterPro:IPR036615	F		Seeded From UniProt
enables	GO:0004326	tetrahydrofolylpolyglutamate synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001645 InterPro:IPR018109	F		Seeded From UniProt
involved_in	GO:0046901	tetrahydrofolylpolyglutamate biosynthetic process	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004326	P		Seeded From UniProt
	GO:0019899		PMID:11197757	ECO:0007681					Fig. 2. Gene structure of gtp-ch, shmt and dhfs}fpgs from Plasmodium falciparum showing relative lengths (excluding the stop codon) and intron positions (shaded boxes; numbers above and below these indicate the 5« and 3« terminal nt positions, respectively, of the introns). Fig. 3. Chromosomal location of the shmt (a) and gtp-ch (c) genes in parasite lines 3D7 (D) and K1 (K). The characteristic size difference in chromosome 12 for these lines assists unambiguous assignation of these genes. Fig. 6. Alignment of the predicted protein sequence of Plasmodium falciparum SHMT with a representative sample of homologous molecules from other organisms, including the cytosolic enzyme from the human host. The corresponding nucleotide sequence encoding the malarial protein has been deposited in the GenBank}EMBL database, accession no. AF195023. Accession nos. for the other protein sequences above are: Y14485 (Homo sapiens), L22529 (Saccharomyces cerevisiae ; cytosolic), M81918 (Neurospora crassa; cytosolic), CAB44976 (Neisseria meningitidis), AAC75604 (Escherichia coli). The upper half of the ethidium bromide-stained gel encompassing chromosomes 10–14 is shown in panel b.	complete
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