PIG:INS

Species (Taxon ID)	Sus scrofa (Pig). (9823)
Gene Name(s)	INS
Protein Name(s)	Insulin Insulin B chain Insulin A chain
External Links
UniProt	P01315
EMBL	AF064555 AY044828 AY242098 AY242099 AY242100 AY242101 AY242102 AY242103 AY242104 AY242105 AY242106 AY242107 AY242108 AY242109 AY242110 AY242111 AY242112
PIR	A01583
RefSeq	NP_001103242.1
UniGene	Ssc.583
PDB	1B17 1B18 1B19 1B2A 1B2B 1B2C 1B2D 1B2E 1B2F 1B2G 1DEI 1IZA 1IZB 1M5A 1MPJ 1SDB 1WAV 1ZEI 1ZNI 2EFA 2G4M 2TCI 2ZPP 3FHP 3GKY 3INS 3MTH 3RTO 3T2A 4A7E 4INS 5D52 5D53 5D54 5D5E 5FB6 5LIS 6INS 7INS 9INS
PDBsum	1B17 1B18 1B19 1B2A 1B2B 1B2C 1B2D 1B2E 1B2F 1B2G 1DEI 1IZA 1IZB 1M5A 1MPJ 1SDB 1WAV 1ZEI 1ZNI 2EFA 2G4M 2TCI 2ZPP 3FHP 3GKY 3INS 3MTH 3RTO 3T2A 4A7E 4INS 5D52 5D53 5D54 5D5E 5FB6 5LIS 6INS 7INS 9INS
ProteinModelPortal	P01315
SMR	P01315
IntAct	P01315
MINT	P01315
STRING	9823.ENSSSCP00000025428
Allergome	2122
PaxDb	P01315
Ensembl	ENSSSCT00000064136
GeneID	397415
KEGG	ssc:397415
CTD	3630
eggNOG	ENOG410J0XC ENOG4111VJB
GeneTree	ENSGT00390000015440
HOVERGEN	HBG006137
InParanoid	P01315
KO	K04526
Reactome	R-SSC-264876 R-SSC-422085 R-SSC-6807878 R-SSC-6811558 R-SSC-74713 R-SSC-74749 R-SSC-74751 R-SSC-74752 R-SSC-77387
EvolutionaryTrace	P01315
Proteomes	UP000008227
GO	GO:0005615 GO:0005179 GO:0042802 GO:0005158 GO:0005159 GO:0002020 GO:0032148 GO:0006953 GO:0046631 GO:0055089 GO:0007186 GO:0042593 GO:0006006 GO:0009101 GO:0008286 GO:0019249 GO:0008610 GO:0042158 GO:0002674 GO:0045922 GO:2000252 GO:0045721 GO:0045818 GO:0050995 GO:0033861 GO:0042177 GO:0032460 GO:0050709 GO:0045861 GO:1903427 GO:0060266 GO:1990535 GO:0030335 GO:0008284 GO:0050715 GO:1902952 GO:0045740 GO:0010628 GO:0046326 GO:0045725 GO:0045821 GO:0046628 GO:0043410 GO:0045840 GO:0051092 GO:0010750 GO:0050731 GO:0014068 GO:0031954 GO:0051897 GO:1900182 GO:0060267 GO:0006521 GO:1903076 GO:0022898 GO:1903576 GO:0042060
InterPro	IPR004825 IPR016179 IPR036438 IPR022353 IPR022352
Pfam	PF00049
PRINTS	PR00277 PR00276
SMART	SM00078
SUPFAM	SSF56994
PROSITE	PS00262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045723	positive regulation of fatty acid biosynthetic process	PMID:14677856^[1]	ECO:0000314			P		Figures 9 and 10 show that treatment with insulin caused an increase in fatty acid synthesis in pig adipocyte-containing primary cultures.	complete CACAO 13440
	GO:0045723	positive regulation of fatty acid biosynthetic process	PMID:14677856^[1]	ECO:0000314			P		Figure 9 shows that treatment with insulin caused an increase in fatty acid synthesis in pig adipocyte-containing primary cultures.	complete CACAO 13441
	GO:0046889	positive regulation of lipid biosynthetic process	PMID:14677856^[1]	ECO:0000314			P		Figure 5 shows that insulin increased the glucose incorporation into lipid(lipid biosynthesis) vs controls in porcine(pig) adipocyte culture..	complete CACAO 13442
	GO:0051006	positive regulation of lipoprotein lipase activity	PMID:14677856^[1]	ECO:0000314			P		Figure 11 shows that chronic exposure to insulin stimulated an increase lipoprotein lipase activity in Pig adipocyte containing primary cultures.	complete CACAO 13443
	GO:0010907	glucose catabolic process	PMID:14677856^[1]	ECO:0000314			P		Figure 1 shows that insulin tended to increase glucose oxidation in pig adipocyte cultures. Requesting new term 'Positive regulation of glucose catabolic process'	complete CACAO 13468
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01317	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:I7CLV3	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:A5PJB2	C		Seeded From UniProt	complete
involved_in	GO:1903576	response to L-arginine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01317	P		Seeded From UniProt	complete
involved_in	GO:1903576	response to L-arginine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:I7CLV3	P		Seeded From UniProt	complete
involved_in	GO:1903576	response to L-arginine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:A5PJB2	P		Seeded From UniProt	complete
enables	GO:0005159	insulin-like growth factor receptor binding	PMID:2967174^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(UBERON:0001911)	Seeded From UniProt	complete
involved_in	GO:0042158	lipoprotein biosynthetic process	PMID:8069456^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009101	glycoprotein biosynthetic process	PMID:8069456^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:8069456^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0008610	lipid biosynthetic process	PMID:8069456^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019249	lactate biosynthetic process	PMID:8069456^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045721	negative regulation of gluconeogenesis	PMID:8069456^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:7782332^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046628	positive regulation of insulin receptor signaling pathway	PMID:7513704^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045740	positive regulation of DNA replication	PMID:7513704^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031954	positive regulation of protein autophosphorylation	PMID:3518947^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:12138094^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23416304^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P01315	F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:2000252	negative regulation of feeding behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:1990535	neuron projection maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:1903076	regulation of protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:1902952	positive regulation of dendritic spine maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:1900182	positive regulation of protein localization to nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0060267	positive regulation of respiratory burst	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0060266	negative regulation of respiratory burst involved in inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0055089	fatty acid homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0050995	negative regulation of lipid catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0050715	positive regulation of cytokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0050709	negative regulation of protein secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0050708	regulation of protein secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0046631	alpha-beta T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0046628	positive regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0045922	negative regulation of fatty acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0045861	negative regulation of proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0045840	positive regulation of mitotic nuclear division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0045821	positive regulation of glycolytic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0045818	negative regulation of glycogen catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0045725	positive regulation of glycogen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	F		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0042177	negative regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0033861	negative regulation of NAD(P)H oxidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0032460	negative regulation of protein oligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0032270	positive regulation of cellular protein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0032148	activation of protein kinase B activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0022898	regulation of transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0010750	positive regulation of nitric oxide mediated signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0006953	acute-phase response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
involved_in	GO:0006521	regulation of cellular amino acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	F		Seeded From UniProt	complete
enables	GO:0005159	insulin-like growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	F		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	F		Seeded From UniProt	complete
involved_in	GO:0002674	negative regulation of acute inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	P		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01308 ensembl:ENSP00000380432	F		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004825 InterPro:IPR016179 InterPro:IPR022352	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004825 InterPro:IPR016179	C		Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0119	P		Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0313	P		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0372	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Ramsay, TG (2003) Porcine leptin inhibits lipogenesis in porcine adipocytes. J. Anim. Sci. 81 3008-17 PubMed GONUTS page
↑ Dehoff, MH et al. (1988) Both type I and II insulin-like growth factor receptor binding increase during lactogenesis in bovine mammary tissue. Endocrinology 122 2412-7 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Segner, H et al. (1994) Cultured trout liver cells: utilization of substrates and response to hormones. In Vitro Cell. Dev. Biol. Anim. 30A 306-11 PubMed GONUTS page
↑ Argetsinger, LS et al. (1995) Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. J. Biol. Chem. 270 14685-92 PubMed GONUTS page
↑ ^5.0 ^5.1 Sasaoka, T et al. (1994) Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor. J. Biol. Chem. 269 13689-94 PubMed GONUTS page
↑ Ellis, L et al. (1986) Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose. Cell 45 721-32 PubMed GONUTS page
↑ Pandini, G et al. (2002) Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J. Biol. Chem. 277 39684-95 PubMed GONUTS page
↑ Babenko, V & Dzwolak, W (2013) Amino acid sequence determinants in self-assembly of insulin chiral amyloid superstructures: role of C-terminus of B-chain in association of fibrils. FEBS Lett. 587 625-30 PubMed GONUTS page

[PMID:14677856-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Ramsay, TG (2003) Porcine leptin inhibits lipogenesis in porcine adipocytes. J. Anim. Sci. 81 3008-17 PubMed GONUTS page

[PMID:2967174-2] Dehoff, MH et al. (1988) Both type I and II insulin-like growth factor receptor binding increase during lactogenesis in bovine mammary tissue. Endocrinology 122 2412-7 PubMed GONUTS page

[PMID:8069456-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Segner, H et al. (1994) Cultured trout liver cells: utilization of substrates and response to hormones. In Vitro Cell. Dev. Biol. Anim. 30A 306-11 PubMed GONUTS page

[PMID:7782332-4] Argetsinger, LS et al. (1995) Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. J. Biol. Chem. 270 14685-92 PubMed GONUTS page

[PMID:7513704-5] 5.0 ^5.1 Sasaoka, T et al. (1994) Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor. J. Biol. Chem. 269 13689-94 PubMed GONUTS page

[PMID:3518947-6] Ellis, L et al. (1986) Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose. Cell 45 721-32 PubMed GONUTS page

[PMID:12138094-7] Pandini, G et al. (2002) Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J. Biol. Chem. 277 39684-95 PubMed GONUTS page

[PMID:23416304-8] Babenko, V & Dzwolak, W (2013) Amino acid sequence determinants in self-assembly of insulin chiral amyloid superstructures: role of C-terminus of B-chain in association of fibrils. FEBS Lett. 587 625-30 PubMed GONUTS page

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PIG:INS

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