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PEPDI:TOXB
Contents
Species (Taxon ID) | Peptoclostridium difficile (Clostridium difficile). (1496) | |
Gene Name(s) | toxB (synonyms: tcdB) | |
Protein Name(s) | Toxin B | |
External Links | ||
UniProt | P18177 | |
EMBL | X53138 X92982 X60984 | |
PIR | A27636 S10317 | |
RefSeq | WP_009902069.1 | |
PDB | 2BVL 2BVM 4NC2 4NP4 | |
PDBsum | 2BVL 2BVM 4NC2 4NP4 | |
ProteinModelPortal | P18177 | |
SMR | P18177 | |
IntAct | P18177 | |
MINT | MINT-2634250 | |
STRING | 272563.CD0660 | |
CAZy | GT44 | |
MEROPS | C80.003 | |
TCDB | 1.C.57.1.1 | |
eggNOG | ENOG4108N67 COG5263 | |
BRENDA | 2.4.1.B62 | |
EvolutionaryTrace | P18177 | |
GO | GO:0020002 GO:0008234 GO:0046527 GO:0009405 | |
InterPro | IPR018337 IPR020974 IPR029044 IPR024770 IPR024772 IPR024769 | |
Pfam | PF01473 PF11713 PF12919 PF12920 PF12918 | |
SUPFAM | SSF53448 | |
PROSITE | PS51771 PS51170 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0009405 |
pathogenesis |
ECO:0000315 |
P |
Figure 2ab utilizes toxin end point titre and cytotoxic effects on Vero and HT29 cells, while figure 2cd measures toxin neutralization assays. Figure 3a measures the time between innoculation and colonization in the hamster specimins between the different mutants. Figure 3b measures the time from colonization to death of the specimins between the different mutant strains. |
complete | |||||
part_of |
GO:0020002 |
host cell plasma membrane |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0046527 |
glucosyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016757 |
transferase activity, transferring glycosyl groups |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0090729 |
toxin activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008234 |
cysteine-type peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Kuehne, SA et al. (2010) The role of toxin A and toxin B in Clostridium difficile infection. Nature 467 711-3 PubMed GONUTS page
- ↑ Kamitani, S et al. (2010) Characterization of the membrane-targeting C1 domain in Pasteurella multocida toxin. J. Biol. Chem. 285 25467-75 PubMed GONUTS page
- ↑ Wu, ZL et al. (2011) Universal phosphatase-coupled glycosyltransferase assay. Glycobiology 21 727-33 PubMed GONUTS page