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PEPDI:TOXB

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Species (Taxon ID) Peptoclostridium difficile (Clostridium difficile). (1496)
Gene Name(s) toxB (synonyms: tcdB)
Protein Name(s) Toxin B
External Links
UniProt P18177
EMBL X53138
X92982
X60984
PIR A27636
S10317
RefSeq WP_009902069.1
PDB 2BVL
2BVM
4NC2
4NP4
PDBsum 2BVL
2BVM
4NC2
4NP4
ProteinModelPortal P18177
SMR P18177
IntAct P18177
MINT MINT-2634250
STRING 272563.CD0660
CAZy GT44
MEROPS C80.003
TCDB 1.C.57.1.1
eggNOG ENOG4108N67
COG5263
BRENDA 2.4.1.B62
EvolutionaryTrace P18177
GO GO:0020002
GO:0008234
GO:0046527
GO:0009405
InterPro IPR018337
IPR020974
IPR029044
IPR024770
IPR024772
IPR024769
Pfam PF01473
PF11713
PF12919
PF12920
PF12918
SUPFAM SSF53448
PROSITE PS51771
PS51170

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0009405

pathogenesis

PMID:20844489[1]

ECO:0000315

P

Figure 2ab utilizes toxin end point titre and cytotoxic effects on Vero and HT29 cells, while figure 2cd measures toxin neutralization assays. Figure 3a measures the time between innoculation and colonization in the hamster specimins between the different mutants. Figure 3b measures the time from colonization to death of the specimins between the different mutant strains.

complete
CACAO 3763

part_of

GO:0020002

host cell plasma membrane

PMID:20534589[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

PMID:20844489[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046527

glucosyltransferase activity

PMID:21081508[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024769

P

Seeded From UniProt

complete

enables

GO:0016757

transferase activity, transferring glycosyl groups

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024770

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

enables

GO:0090729

toxin activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0800

F

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

enables

GO:0008234

cysteine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0788

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Kuehne, SA et al. (2010) The role of toxin A and toxin B in Clostridium difficile infection. Nature 467 711-3 PubMed GONUTS page
  2. Kamitani, S et al. (2010) Characterization of the membrane-targeting C1 domain in Pasteurella multocida toxin. J. Biol. Chem. 285 25467-75 PubMed GONUTS page
  3. Wu, ZL et al. (2011) Universal phosphatase-coupled glycosyltransferase assay. Glycobiology 21 727-33 PubMed GONUTS page