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PENCH:AAAA

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Species (Taxon ID) Penicillium chrysogenum (Penicillium notatum). (5076)
Gene Name(s) penDE (synonyms: aat)
Protein Name(s) Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form

Isopenicillin-N N-acyltransferase Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 11 kDa subunit Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 29 kDa subunit

External Links
UniProt P15802
EMBL M31454
A15528
A15359
PIR JQ0118
PDB 2X1C
2X1D
2X1E
PDBsum 2X1C
2X1D
2X1E
MEROPS C45.001
PhylomeDB P15802
BioCyc MetaCyc:MONOMER-13369
UniPathway UPA00149
EvolutionaryTrace P15802
PMAP-CutDB P15802
GO GO:0050640
GO:0017000
InterPro IPR005079
Pfam PF03417

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

Contributes to

GO:0050640

isopenicillin-N N-acyltransferase activity

PMID:8344300[1]

ECO:0000314

F

Responsible for isopenicillin-N amidohydrolase, 6-aminopenicillanic acid acyltransferase and penicillin amidase activities in P. chrysogenum.

Mutants npe6, npe8 and npe10 with no acyltransferase activity were transformed with a plamsid, pULB101, containing penDE gene. Mutants were then prepared and assayed. Npe6, npe8 and npe10 showed AAT, IAT, IPN amidohydrolase, penicillin transacylase and penicllin amidase activities. This indicated the penDE gene recovered all acyltransferase activity. Table 6 shows the results of an assay for the comparison between P. chrysogenum and C. acremonium. C. acremonium does not contain the penDE gene and recorded zero activity for Acyl-CoA:CAPA acyltransferase activity, extracellular accumulation of 6-APA, and production of penicillin. Whereas, P. chrysogenum does contain the penDE gene and showed positive results for these activities.


complete
CACAO 4068

enables

GO:0102920

acyl coenzyme A: isopenicillin N acyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.3.1.164

F

Seeded From UniProt

complete

enables

GO:0050640

isopenicillin-N N-acyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.3.1.164

F

Seeded From UniProt

complete

enables

GO:0016746

transferase activity, transferring acyl groups

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0012

F

Seeded From UniProt

complete

involved_in

GO:0017000

antibiotic biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0045

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Alvarez, E et al. (1993) The isopenicillin-N acyltransferase of Penicillium chrysogenum has isopenicillin-N amidohydrolase, 6-aminopenicillanic acid acyltransferase and penicillin amidase activities, all of which are encoded by the single penDE gene. Eur. J. Biochem. 215 323-32 PubMed GONUTS page