PENCH:AAAA

Species (Taxon ID)	Penicillium chrysogenum (Penicillium notatum). (5076)
Gene Name(s)	penDE (synonyms: aat)
Protein Name(s)	Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form Isopenicillin-N N-acyltransferase Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 11 kDa subunit Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 29 kDa subunit
External Links
UniProt	P15802
EMBL	M31454 A15528 A15359
PIR	JQ0118
PDB	2X1C 2X1D 2X1E
PDBsum	2X1C 2X1D 2X1E
MEROPS	C45.001
PhylomeDB	P15802
BioCyc	MetaCyc:MONOMER-13369
UniPathway	UPA00149
EvolutionaryTrace	P15802
PMAP-CutDB	P15802
GO	GO:0050640 GO:0017000
InterPro	IPR005079
Pfam	PF03417

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
Contributes to	GO:0050640	isopenicillin-N N-acyltransferase activity	PMID:8344300	ECO:0000314			F		Responsible for isopenicillin-N amidohydrolase, 6-aminopenicillanic acid acyltransferase and penicillin amidase activities in P. chrysogenum. Mutants npe6, npe8 and npe10 with no acyltransferase activity were transformed with a plamsid, pULB101, containing penDE gene. Mutants were then prepared and assayed. Npe6, npe8 and npe10 showed AAT, IAT, IPN amidohydrolase, penicillin transacylase and penicllin amidase activities. This indicated the penDE gene recovered all acyltransferase activity. Table 6 shows the results of an assay for the comparison between P. chrysogenum and C. acremonium. C. acremonium does not contain the penDE gene and recorded zero activity for Acyl-CoA:CAPA acyltransferase activity, extracellular accumulation of 6-APA, and production of penicillin. Whereas, P. chrysogenum does contain the penDE gene and showed positive results for these activities.	complete CACAO 4068
enables	GO:0102920	acyl coenzyme A: isopenicillin N acyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.164	F		Seeded From UniProt	complete
enables	GO:0050640	isopenicillin-N N-acyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.164	F		Seeded From UniProt	complete
enables	GO:0016746	transferase activity, transferring acyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0012	F		Seeded From UniProt	complete
involved_in	GO:0017000	antibiotic biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0045	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
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References

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