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PARDP:4HYPE

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Species (Taxon ID) Paracoccus denitrificans (strain Pd 1222). (318586)
Gene Name(s) hypF
Protein Name(s) 4-hydroxyproline 2-epimerase (ECO:0000303 with PMID:24056934[1], ECO:0000303 with PMID:24980702[2])

4Hyp 2-epimerase (ECO:0000303 with PMID:24056934[1]) 4HypE (ECO:0000303 with PMID:24980702[2])

External Links
UniProt A1BBM5
EMBL CP000491
RefSeq WP_011751078.1
ProteinModelPortal A1BBM5
EnsemblBacteria ABL72919
KEGG pde:Pden_4859
PATRIC 22860945
HOGENOM HOG000084336
KO K12658
OMA EAYCHES
OrthoDB EOG6SNDV3
BioCyc PDEN318586:GCVQ-4902-MONOMER
Proteomes UP000000361
GO GO:0047580
GO:0006579
InterPro IPR008794
Pfam PF05544
PIRSF PIRSF029792

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0047580

4-hydroxyproline epimerase activity

PMID:24980702[2]

ECO:0000314

F

Table 2 contains the kinetic parameters for the reaction, the uniprot ID and the assigned function. (4R-hydroxyproline 2-epimerase is 4HypE). Although the kcat/Km value is low, based on genome neighborhood information, the authors conclude this is the function.

  • Note has been changed

complete
CACAO 10173

enables

GO:0047580

4-hydroxyproline epimerase activity

PMID:24980702[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0047580

4-hydroxyproline epimerase activity

PMID:24056934[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006579

amino-acid betaine catabolic process

PMID:24056934[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0047580

4-hydroxyproline epimerase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:5.1.1.8

F

Seeded From UniProt

complete

enables

GO:0016853

isomerase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0413

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Zhao, S et al. (2013) Discovery of new enzymes and metabolic pathways by using structure and genome context. Nature 502 698-702 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Zhao, S et al. (2014) Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks. Elife 3 PubMed GONUTS page