ONCMY:Q5QSL2

Species (Taxon ID)	Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri). (8022)
Gene Name(s)	ifng (ECO:0000313 with EMBL:CAE82300.1)
Protein Name(s)	Interferon gamma (ECO:0000313 with EMBL:CAE82300.1)
External Links
UniProt	Q5QSL2
EMBL	AJ616215
RefSeq	NP_001118092.1
UniGene	Omy.16659
ProteinModelPortal	Q5QSL2
GeneID	100136643
CTD	3458
HOVERGEN	HBG105659
GO	GO:0005576 GO:0006955
Gene3D	1.20.1250.10
InterPro	IPR009079 IPR012351 IPR002069
PANTHER	PTHR11419
Pfam	PF00714
ProDom	PD002435
SUPFAM	SSF47266

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0010628	positive regulation of gene expression	PMID:20353564^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	PMID:20353564^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032897	negative regulation of viral transcription	PMID:21697489^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:21697489^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904972	negative regulation of viral translation	PMID:21697489^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:21697489^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045918	negative regulation of cytolysis	PMID:21697489^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031342	negative regulation of cell killing	PMID:21697489^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033365	protein localization to organelle	PMID:23452377^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000113) occurs_in:(UBERON:0007132) occurs_in:(GO:0036019)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23452377^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000113) occurs_in:(UBERON:0007132) occurs_in:(GO:0036019)	Seeded From UniProt	complete
enables	GO:0005133	interferon-gamma receptor binding	PMID:19454334^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:B6RLL1	F		Seeded From UniProt	complete
enables	GO:0005133	interferon-gamma receptor binding	PMID:19454334^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:A0A060WMK8	F		Seeded From UniProt	complete
enables	GO:0005133	interferon-gamma receptor binding	PMID:19454334^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:A0A060YX94	F		Seeded From UniProt	complete
enables	GO:0005133	interferon-gamma receptor binding	PMID:19454334^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:A1IMH9	F		Seeded From UniProt	complete
enables	GO:0005133	interferon-gamma receptor binding	PMID:19454334^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:B6RLL0	F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:19454334^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:19454334^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	PMID:24582990^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060333	interferon-gamma-mediated signaling pathway	PMID:24582990^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:24582990^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060267	positive regulation of respiratory burst	PMID:16081820^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000235) occurs_in:(UBERON:0007132)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:16081820^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0007132) occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:17549796^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0007132)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:17549796^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0007132)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:18805586^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005133	interferon-gamma receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002069	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002069	C		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002069	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Skjesol, A et al. (2010) Structural and functional studies of STAT1 from Atlantic salmon (Salmo salar). BMC Immunol. 11 17 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Sun, B et al. (2011) Antiviral activity of salmonid gamma interferon against infectious pancreatic necrosis virus and salmonid alphavirus and its dependency on type I interferon. J. Virol. 85 9188-98 PubMed GONUTS page
↑ ^3.0 ^3.1 Iliev, DB et al. (2013) CpG oligonucleotides bind TLR9 and RRM-containing proteins in Atlantic salmon (Salmo salar). BMC Immunol. 14 12 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Gao, Q et al. (2009) The search for the IFN-gamma receptor in fish: Functional and expression analysis of putative binding and signalling chains in rainbow trout Oncorhynchus mykiss. Dev. Comp. Immunol. 33 920-31 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Skjesol, A et al. (2014) Functional conservation of suppressors of cytokine signaling proteins between teleosts and mammals: Atlantic salmon SOCS1 binds to JAK/STAT family members and suppresses type I and II IFN signaling. Dev. Comp. Immunol. 45 177-89 PubMed GONUTS page
↑ ^6.0 ^6.1 Zou, J et al. (2005) Identification and bioactivities of IFN-gamma in rainbow trout Oncorhynchus mykiss: the first Th1-type cytokine characterized functionally in fish. J. Immunol. 175 2484-94 PubMed GONUTS page
↑ ^7.0 ^7.1 Martin, SA et al. (2007) Proteome analysis of the Atlantic salmon (Salmo salar) cell line SHK-1 following recombinant IFN-gamma stimulation. Proteomics 7 2275-86 PubMed GONUTS page
↑ Holland, JW et al. (2008) Molecular characterization of IRF3 and IRF7 in rainbow trout, Oncorhynchus mykiss: functional analysis and transcriptional modulation. Mol. Immunol. 46 269-85 PubMed GONUTS page

[PMID:20353564-1] 1.0 ^1.1 Skjesol, A et al. (2010) Structural and functional studies of STAT1 from Atlantic salmon (Salmo salar). BMC Immunol. 11 17 PubMed GONUTS page

[PMID:21697489-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Sun, B et al. (2011) Antiviral activity of salmonid gamma interferon against infectious pancreatic necrosis virus and salmonid alphavirus and its dependency on type I interferon. J. Virol. 85 9188-98 PubMed GONUTS page

[PMID:23452377-3] 3.0 ^3.1 Iliev, DB et al. (2013) CpG oligonucleotides bind TLR9 and RRM-containing proteins in Atlantic salmon (Salmo salar). BMC Immunol. 14 12 PubMed GONUTS page

[PMID:19454334-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Gao, Q et al. (2009) The search for the IFN-gamma receptor in fish: Functional and expression analysis of putative binding and signalling chains in rainbow trout Oncorhynchus mykiss. Dev. Comp. Immunol. 33 920-31 PubMed GONUTS page

[PMID:24582990-5] 5.0 ^5.1 ^5.2 Skjesol, A et al. (2014) Functional conservation of suppressors of cytokine signaling proteins between teleosts and mammals: Atlantic salmon SOCS1 binds to JAK/STAT family members and suppresses type I and II IFN signaling. Dev. Comp. Immunol. 45 177-89 PubMed GONUTS page

[PMID:16081820-6] 6.0 ^6.1 Zou, J et al. (2005) Identification and bioactivities of IFN-gamma in rainbow trout Oncorhynchus mykiss: the first Th1-type cytokine characterized functionally in fish. J. Immunol. 175 2484-94 PubMed GONUTS page

[PMID:17549796-7] 7.0 ^7.1 Martin, SA et al. (2007) Proteome analysis of the Atlantic salmon (Salmo salar) cell line SHK-1 following recombinant IFN-gamma stimulation. Proteomics 7 2275-86 PubMed GONUTS page

[PMID:18805586-8] Holland, JW et al. (2008) Molecular characterization of IRF3 and IRF7 in rainbow trout, Oncorhynchus mykiss: functional analysis and transcriptional modulation. Mol. Immunol. 46 269-85 PubMed GONUTS page

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ONCMY:Q5QSL2

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