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ONCMY:Q5QSL2

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Species (Taxon ID) Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri). (8022)
Gene Name(s) ifng (ECO:0000313 with EMBL:CAE82300.1)
Protein Name(s) Interferon gamma (ECO:0000313 with EMBL:CAE82300.1)
External Links
UniProt Q5QSL2
EMBL AJ616215
RefSeq NP_001118092.1
UniGene Omy.16659
ProteinModelPortal Q5QSL2
GeneID 100136643
CTD 3458
HOVERGEN HBG105659
GO GO:0005576
GO:0006955
Gene3D 1.20.1250.10
InterPro IPR009079
IPR012351
IPR002069
PANTHER PTHR11419
Pfam PF00714
ProDom PD002435
SUPFAM SSF47266

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0010628

positive regulation of gene expression

PMID:20353564[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

PMID:20353564[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032897

negative regulation of viral transcription

PMID:21697489[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:21697489[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1904972

negative regulation of viral translation

PMID:21697489[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:21697489[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045918

negative regulation of cytolysis

PMID:21697489[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031342

negative regulation of cell killing

PMID:21697489[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033365

protein localization to organelle

PMID:23452377[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(CL:0000113)
  • occurs_in:(UBERON:0007132)
  • occurs_in:(GO:0036019)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:23452377[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(CL:0000113)
  • occurs_in:(UBERON:0007132)
  • occurs_in:(GO:0036019)

Seeded From UniProt

complete

enables

GO:0005133

interferon-gamma receptor binding

PMID:19454334[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:B6RLL1

F

Seeded From UniProt

complete

enables

GO:0005133

interferon-gamma receptor binding

PMID:19454334[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:A0A060WMK8

F

Seeded From UniProt

complete

enables

GO:0005133

interferon-gamma receptor binding

PMID:19454334[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:A0A060YX94

F

Seeded From UniProt

complete

enables

GO:0005133

interferon-gamma receptor binding

PMID:19454334[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:A1IMH9

F

Seeded From UniProt

complete

enables

GO:0005133

interferon-gamma receptor binding

PMID:19454334[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:B6RLL0

F

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:19454334[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

PMID:19454334[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046427

positive regulation of receptor signaling pathway via JAK-STAT

PMID:24582990[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060333

interferon-gamma-mediated signaling pathway

PMID:24582990[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

PMID:24582990[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060267

positive regulation of respiratory burst

PMID:16081820[6]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(CL:0000235)
  • occurs_in:(UBERON:0007132)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:16081820[6]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(UBERON:0007132)
  • occurs_in:(CL:0000235)

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

PMID:17549796[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0007132)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:17549796[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0007132)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:18805586[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005133

interferon-gamma receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002069

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002069

C

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002069

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Skjesol, A et al. (2010) Structural and functional studies of STAT1 from Atlantic salmon (Salmo salar). BMC Immunol. 11 17 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Sun, B et al. (2011) Antiviral activity of salmonid gamma interferon against infectious pancreatic necrosis virus and salmonid alphavirus and its dependency on type I interferon. J. Virol. 85 9188-98 PubMed GONUTS page
  3. 3.0 3.1 Iliev, DB et al. (2013) CpG oligonucleotides bind TLR9 and RRM-containing proteins in Atlantic salmon (Salmo salar). BMC Immunol. 14 12 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Gao, Q et al. (2009) The search for the IFN-gamma receptor in fish: Functional and expression analysis of putative binding and signalling chains in rainbow trout Oncorhynchus mykiss. Dev. Comp. Immunol. 33 920-31 PubMed GONUTS page
  5. 5.0 5.1 5.2 Skjesol, A et al. (2014) Functional conservation of suppressors of cytokine signaling proteins between teleosts and mammals: Atlantic salmon SOCS1 binds to JAK/STAT family members and suppresses type I and II IFN signaling. Dev. Comp. Immunol. 45 177-89 PubMed GONUTS page
  6. 6.0 6.1 Zou, J et al. (2005) Identification and bioactivities of IFN-gamma in rainbow trout Oncorhynchus mykiss: the first Th1-type cytokine characterized functionally in fish. J. Immunol. 175 2484-94 PubMed GONUTS page
  7. 7.0 7.1 Martin, SA et al. (2007) Proteome analysis of the Atlantic salmon (Salmo salar) cell line SHK-1 following recombinant IFN-gamma stimulation. Proteomics 7 2275-86 PubMed GONUTS page
  8. Holland, JW et al. (2008) Molecular characterization of IRF3 and IRF7 in rainbow trout, Oncorhynchus mykiss: functional analysis and transcriptional modulation. Mol. Immunol. 46 269-85 PubMed GONUTS page